Urethane-induced hyperglycemia  

乌拉坦诱导的高血糖反应(英文)

作　　者：王旻艳[1] 任雷鸣[2] 杜战江 傅绍萱[2] 

机构地区：[1]河北省药品检验所,石家庄050011 [2]河北医科大学药理学教研室,石家庄050017 [3]石家庄市药品检验所

出　　处：《Acta Pharmacologica Sinica》2000年第3期81-85,共5页中国药理学报（英文版）

基　　金：Project supported by Hebei Postdoctoral Research Foundation № 1997-02.

摘　　要：AIM: To study the effects of urethane, at anesthetic dose, on the blood glucose levels in normal rats and hy-perglycemic rats, and its effects on the hypoglycemic action of exogenous insulin in alloxan-treated rats. METHODS: Blood glucose concentration was measured with the glucose oxidase method. RESULTS: Urethane at anesthetic dose 1.5 g·kg-1 increased the blood glucose levels in fasting (to 2.6±0.3 g·L-1, P<0.01) or glucose-loaded (to 3.9±0.4 g·L-1, P< 0.01) rats. It did not modify the hyperglycemia induced by epinephrine (normal islet β-cells) or alloxan (impaired islet β-cells). In the rats treated with alloxan, blood glucose level decreased to 1.8±0.7 g·L-1 at 200 min after administration of insulin from control level of 7.0±2.3 g·L-1, but the hypoglycemic action of exogenous insulin was abolished by urethane. CONCLUSION: Hyper-glycemic action of urethane was due to its inhibiting effect on the hypoglycemic effect of insulin, except for its known mechanism of increased sympathetic release.目的:观察麻醉剂量的乌拉坦对空腹大鼠、葡萄糖负荷大鼠,肾上腺素或四氧嘧啶诱发高血糖大鼠血糖水平的影响,并探讨其对外源性胰岛素降血糖作用的影响。方法:葡萄糖氧化酶法测定血糖含量。结果:麻醉剂量1.5g·kg^(-1)乌拉坦(sc,ip各半)显著升高空腹大鼠和葡萄糖负荷大鼠的血糖水平,但对肾上腺素(胰岛功能正常)或四氧嘧啶(胰岛功能受损)诱发的高血糖大鼠的血糖水平无明显影响。在四氧嘧啶诱发的高血糖大鼠,乌拉坦显著对抗外源性胰岛素的降血糖作用。结论:乌拉坦升高血糖的作用除与已知的释放肾上腺素有关外,抑制胰岛素的降血糖作用也是其升高血糖的机制之一。

关 键 词：URETHANE blood glucose INSULIN EPINEPHRINE ALLOXAN FASTING 

分 类 号：R96[医药卫生—药理学]