Moclobemide-induced gynecomastia in rats  

吗氯贝胺源性雄鼠乳腺发育症(英文)

作　　者：马小超[1] 王莹 刘建华 屠曾宏 

机构地区：[1]中国科学院上海药物研究所新药研究国家重点实验室

出　　处：《Acta Pharmacologica Sinica》2000年第10期32-35,共4页中国药理学报（英文版）

摘　　要：AIM:To study the toxic effect of moclobemide on male breast and to elucidate its mechanism of action. METHODS: Routine histopathological analysis was used to diagnose the effect of moclobemide on male breast in rats. Plasma concentrations of estrogen, androgen, and prolactin were measured by a ratioimmunometer and relative receptors of mammary gland tissue were detected im-munohistochemically. RESULTS:After 180-d moclobemide treatment, the presence of gynecomastia was 0, 5, 5, 7/10 rats in 0, 60, 240, and 600 mg/kg groups, respectively. After 30-d convalescence, only one rat in 600 mg/kg group got the incidence of gynecomastia . Serum prolactin concentration had a trend to decrease with increasing dose and prolactin receptors in mammary gland were up-regulated. CONCLUSION: Long-term treatment with moclobemide causes gynecomastia in rats, which is reversible. The mechanism of moclobemide-induced gynecomastia may be related to the increase in prolactin receptors in mammary glands.目的:研究吗氯贝胺的乳腺毒性及其可能机制.方法:用组织病理学方法判断吗氯贝胺对乳腺的影响,用免疫荧光的方法检测雄激素、雌激素和催乳素的血清浓度,并用免疫组织化学方法半定量测定相关受体的变化.结果:180 d时对照组、60、240、600 mg/kg给药组分别有0、5、5、7只大鼠乳腺发育,30 d恢复期后仅600mg/kg组有1只大鼠乳腺发育.血清催乳素的浓度随着给药剂量的升高而下降,乳腺组织催乳素受体上调.结论:长期服用吗氯贝胺可引起可逆性雄性大鼠乳腺发育,异常发育的机制可能与催乳素受体上调有关.

关 键 词：MOCLOBEMIDE TOXICITY GYNECOMASTIA PROLACTIN prolactin receptors RAT 

分 类 号：R655.8[医药卫生—外科学]