Abnormal expression of inducible nitric oxide synthase in Duchenne muscular dystrophy muscles  

作　　者：Minsheng Zhu Yuhua Fan Xiangyu Xu Gang Wang Yue Shen Ying Pan Shubiao Ding 

机构地区：[1]Nanjing Mil Inst Med Sci, Nanjing 210002, Peoples R China [2]Nanjing Children Hosp, Dept Neurol, Nanjing 210005, Peoples R China

出　　处：《Chinese Science Bulletin》1998年第10期860-863,共4页

摘　　要：Duchenne muscular dystrophy (DMD) is a fatal genetic disease for the youth and children. 8 biopsies of DMD patients were determined and demonstrated that the membrane_binding nitric oxide synthase was enriched in normal skeletal muscles and was little in DMD muscles. The results from Western blot and immunohistochemistry showed that inducible nitric oxide synthase (iNOS) was overexpressed in DMD muscle fibers, while a small amount of highly localized iNOS can be found in normal fibers. Based on these findings, it is proposed that the mechanism of progressive injury in DMD muscle might be associated with the abnormal expression of iNOS.Duchenne muscular dystrophy (DMD) is a fatal genetic disease for the youth and children. 8 biopsies of DMD patients were determined and demonstrated that the membrane-binding nitric oxide synthase was enriched in normal skeletal muscles and was little in DMD muscles. The results from Western blot and immunohistochemistry showed that inducible nitric oxide synthase (iN-OS) was overexpressed in DMD muscle fibers, while a small amount of highly localized iNOS can be found in normal fibers. Based on these findings, it is proposed that the mechanism of progressive injury in DMD muscle might be associated with the abnormal expression of iNOS.

关 键 词：DUCHENNE MUSCULAR DYSTROPHY INDUCIBLE NITRIC oxide SYNTHASE human. 

分 类 号：Q789[生物学—分子生物学]