Tumor radioimmunoimaging of chimeric antibody in nude mice with hepatoma xenograft  

作　　者：GONG Yi LIU Kang-Da ZHOU Ge XUE Qiong CHEN Shao-Liang TANG Zhao-You 

机构地区：[1]不详

出　　处：《World Journal of Gastroenterology》1998年第1期12-14,共3页世界胃肠病学杂志（英文版）

摘　　要：IM To study the radioimmunoimaging (RAII) using the human/mouse chimeric Ab to evaluate its targeting activity in animal models.METHODS To chimeric Ab was labeled with 131I. RAII was performed at different intervals after injection of radiolabeled Abs in nude mice with human hepatoma xenograft, and tissue distribution of radioactivity was measured. Comparison was made in the chimeric Ab between the single segment Ab and previous murine mAb against HBxAg.RESULTS The experimental objects developed tumorpositive image after 2 days of radiolabeled Abs injection, and the peak accumulation of radioactivity fell on the 7th day. The tumor/liver ratioactivity of the chimeric Ab, single segment Ab, antiHBx mAb, and the control group was 281±021, 244±016, 460±019, and 096±014, respectively.CONCLUSION The genetic engineering Abs have a considerable targeting activity which can be used as a novel humanized vector in the targeting treatment of liver cancer..ＴｕｍｏｒｒａｄｉｏｉｍｍｕｎｏｉｍａｇｉｎｇｏｆｃｈｉｍｅｒｉｃａｎｔｉｂｏｄｙｉｎｎｕｄｅｍｉｃｅｗｉｔｈｈｅｐａｔｏｍａｘｅｎｏｇｒａｆｔＧＯＮＧＹｉ１，ＬＩＵＫａｎｇＤａ１，ＺＨＯＵＧｅ１，ＸＵＥＱｉｏｎｇ１，ＣＨＥＮＳｈａｏＬｉａｎｇ...

关 键 词：liver neoplasms  experimental carcinoma  hepatocellular chimeric antibody mice  nude hepatitis B virus disease models  animal RADIOIMMUNODETECTION RADIOIMMUNOTHERAPY 

分 类 号：R735.7[医药卫生—肿瘤]