RADIOIMMUNOTHERAPY

作品数：28被引量：43H指数：3
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相关领域：医药卫生更多>>
相关作者：宋向群黄秉琰吴英德杨克政周德南更多>>
相关机构：广西医科大学附属肿瘤医院更多>>
相关期刊：《Nano-Micro Letters》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划王宽诚敎育基金更多>>
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Therapeutic Characterization of ^(131)I-Labeled Humanized Anti-B7-H3 Antibodies for Radioimmunotherapy for Glioblastoma
《Engineering》2023年第11期190-202,共13页Fengqing Fu Meng Zheng Shandong Zhao Yan Wang Minzhou Huang Hanqing Chen Ziyi Huang Kaijie Zhang Liyan Miao Xueguang Zhang 
funded by the National Natural Science Foundation of China(31320103918 and 82104318);Key Research and Development Program of Jiangsu Province(BE2021644);the Jiangsu Innovative and Entrepreneurial Talent Programme(JSSCBS20211568);the Science and Technology Plan of Suzhou(SKJYD2021161 and SKY2022046);Key Project of Jiangsu Provincial Health Commission(zd2021050);the Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University(GZK1202203);support of Jiangsu Institute of Nuclear Medicine for the ^(89)Zr-PET imaging in this study。
B7 homolog 3(B7-H3)has attracted much attention in glioblastoma(GBM)radioimmunotherapy(RIT)due to its abnormally high expression on tumor cells.In this study,we report that two specific humanized anti-human B7-H3 anti...
关键词：B7-H3 RADIOIMMUNOTHERAPY GLIOBLASTOMA PHARMACOKINETICS PHARMACODYNAMICS 
Tellurium-driven maple leaf-shaped manganese nanotherapeutics reshape tumor microenvironment via chemical transition in situ to achieve highly efficient radioimmunotherapy of triple negative breast cancer被引量：1
《Bioactive Materials》2023年第9期560-573,共14页Wei Huang Sujiang Shi Haoran Lv Zhenyu Ju Qinghua Liu Tianfeng Chen 
supported by National Science Fund for Distinguished Young Scholars(82225025);National Natural Science Foundation of China(21877049,32171296,32201166,82172088);Guangdong Natural Science Foundation(2020B1515120043);Guangdong Basic and Applied Basic Research Fund Project(No.2021A1515111027);K.C.Wong Education Foundation.
The therapeutic efficacy of radioimmunotherapy against triple negative breast cancer(TNBC)is largely limited by the complicated tumor microenvironment(TME)and its immunosuppressive state.Thus developing a strategy to ...
关键词：RADIOIMMUNOTHERAPY Triple negative breast cancer TELLURIUM Manganese carbonate Tumor microenvironment 
Radioimmunotherapy-induced intratumoral changes in cervical squamous cell carcinoma at single-cell resolution
《Cancer Communications》2022年第12期1407-1411,共5页Chao Liu Hao Yu Rui Huang Tianyu Lei Xiaohui Li Ming Liu Qingyu Huang Qilian Du Ligang Xing Jinming Yu 
supported by funds fromtheNationalNatural Science Foundation of China(82030082);the Academic Promotion Program of Shandong First Medical University(2019ZL002);the Radiation Oncology Innovate Unit,Chinese Academy of Medical Sciences(2019RU071);Key Research and Development Project of Shandong Province of China(2021CXGC011102);Shandong Provincial Natural Science Foundation(ZR2021QH006);Beijing Bethune Charitable Foundation(flzh202118).
Dear Editor,Increasing numbers of studies have revealed the immunomodulating effects of radiotherapy when combined with immune checkpoint inhibitors,as radioimmunotherapy has proven to be a promising treatment[1].Radi...
关键词：CERVICAL CHEMOTHERAPY treatment 
Therapeutic dendritic cell vaccines engineered with antigen-biomineralized Bi_(2)S_(3) nanoparticles for personalized tumor radioimmunotherapy被引量：1
《Aggregate》2022年第5期227-237,共11页Huan Yu Haoxiang Guo He Zu Heng Ding Subin Lin Yangyun Wang Leshuai W Zhang Yong Wang 
National Natural Science Foundation of China,Grant/Award Numbers:22122407,12175162,32171403,12075164,31971319,21874097;National Key Research Program of China,Grant/Award Number:2018YFA0208800;Tang Scholar Program;Scientific Research Program for Young Talents of China National Nuclear Corporation and A Priority Academic Program Development of Jiangsu Higher Education Institutions。
Therapeutic vaccines,an exciting development in cancer immunotherapy,share the goal of priming of personalized antigen-specific T-cell response by precise antigen presentation of dendritic cells(DCs),but major obstacl...
关键词：antigen-biomineralized Bi_(2)S_(3)nanoparticles dendritic cells RADIOIMMUNOTHERAPY therapeutic vaccines visualization 
Bacteria-assisted delivery and oxygen production of nano-enzyme for potent radioimmunotherapy of cancer被引量：2
《Nano Research》2022年第8期7355-7365,共11页Jing Ni Hailin Zhou Jingyu Gu Xinpei Liu Jie Chen Xuan Yi Kai Yang 
the National Natural Science Foundation of China(Nos.32171382,U1932208 U2032134,and 31900986);the Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University(No.GZK1202110);the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
Tumor-targeting attenuated Salmonella could induce certain antitumor therapeutic effect through its proliferation characteristic and the consequent activated immune response,while host defense cells represented by neu...
关键词：bacteria NEUTROPHIL hydrogen peroxide denatured albumin RADIOTHERAPY 
Screening for a^(177)Lu-labeled CA19–9 monoclonal antibody via PET imaging for colorectal cancer therapy被引量：1
《Chinese Chemical Letters》2022年第7期3502-3506,共5页Jing Wang Liangang Zhuo Peng Zhao Wei Liao Hongyuan Wei Yuchuan Yang Shuming Peng Xia Yang 
supported by the National Natural Science Foundation of China(Nos.21976167,U20A20384);the CAEP Innovation and Development Foundation(No.CX20200003);Nuclear Energy Development Project of State Administration of Science,Technology and Industry for National Defense(No.20201192–1);Key R&D Project of Sichuan Science and Technology Program(No.2020YFS0030);the Central Guidance for Local Science and Technology Development Projects(No.202138–03)。
Carbohydrate antigen 19–9(CA19–9)with multi epitopes relatively high expresses on colorectal cancer(CRC)cells,making it an attractive target for developing radioimmunotherapy(RIT)for CRC.The lutetium-177(^(177)Lu)la...
关键词：Lutetium-177 CA19–9 Monoclonal antibody Colorectal cancer RADIOIMMUNOTHERAPY 
Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy
《Nano-Micro Letters》2020年第8期116-129,共14页Xuanfang Zhou Zhouqi Meng Jialin She Yaojia Zhang Xuan Yi Hailin Zhou Jing Zhong Ziliang Dong Xiao Han Muchao Chen Qin Fan Kai Yang Chao Wang 
This work is supported by grants from startup supports of Soochow University and the Program for Jiangsu Specially Appointed Professors to C.W;This work is partly supported by Collaborative Innovation Center of Suzhou Nano Science&Technology,the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),the 111 Project;This work was also supported by the National Natural Science Foundation of China(No.31900988);the Natural Science Foundation of Jiangsu Province(No.SBK2019040088);Jiangsu Province Six Talent Peaks Project(No.SWYY-110).
Radiotherapy(RT)is a widely used way for cancer treatment.However,the efficiency of RT may come with various challenges such as low specificity,limitation by resistance,high dose and so on.Nitric oxide(NO)is known a v...
关键词：NO delivery Radio sensitivity Multifunctional agent RADIOIMMUNOTHERAPY Drug delivery 
Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/m TOR inhibitor
《World Journal of Gastroenterology》2017年第42期7551-7562,共12页Winn Aung Atsushi B Tsuji Hitomi Sudo Aya Sugyo Yoshinori Ukai Katsushi Kouda Yoshikazu Kurosawa Takako Furukawa Tsuneo Saga Tatsuya Higashi 
Supported by(partially)a Grant-in-Aid for Scientific Research(C)from the Ministry of Education,Culture,Sports,Science and Technology,Japan,No.17K10460 to Aung W
AIM To investigate the therapeutic effect of combined integrin α6β4-targeted radioimmunotherapy(RIT) and PI3 K/m TOR inhibitor BEZ235 in a pancreatic cancer model.METHODS Phosphorylation of Akt, m TOR, the downstrea...
关键词：RADIOIMMUNOTHERAPY Pancreatic cancer Anti-integrin α6β4 antibody Yttrium-90 NVP-BEZ235 
Activity estimation in radioimmunotherapy using magnetic nanoparticles被引量：1
《Chinese Journal of Cancer Research》2015年第2期203-208,共6页Samira Rasaneh Hossein Rajabi Fariba Johari Daha 
Objective： Estimation of activity accumulated in tumor and organs is very important in predicting the response of radiopharmaceuticals treatment. In this study, we synthesized ~77Lutetium （177Lu）-trastuzumabiron ox...
关键词：Radioimmunotherapy （RIT） activity estimation lutetium-177 HERCEPTIN magnetic nanoparticles magnetic resonance imaging （MRI） 
Therapeutic radionuclides in nuclear medicine: current and future prospects被引量：7
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2014年第10期845-863,共19页Chai-Hong YEONG Mu-hua CHENG Kwan-Hoong NG 
The potential use of radionuclides in therapy has been recognized for many decades. A number of radionuclides, such as iodine-131（^131I）, phosphorous-32（^32P）, strontium-90（^90Sr）, and yttrium-90（^90Y）, have b...
关键词：Therapeutic radionuclide Targeted radionuclide therapy RADIOIMMUNOTHERAPY Molecular targeting THERANOSTICS 
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