Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy  

作　　者：Xuanfang Zhou Zhouqi Meng Jialin She Yaojia Zhang Xuan Yi Hailin Zhou Jing Zhong Ziliang Dong Xiao Han Muchao Chen Qin Fan Kai Yang Chao Wang 

机构地区：[1]Institute of Functional Nano and Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou 215123,Jiangsu,People’s Republic of China [2]State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences(RAD-X),Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,Jiangsu,People’s Republic of China

出　　处：《Nano-Micro Letters》2020年第8期116-129,共14页纳微快报（英文版）

基　　金：This work is supported by grants from startup supports of Soochow University and the Program for Jiangsu Specially Appointed Professors to C.W;This work is partly supported by Collaborative Innovation Center of Suzhou Nano Science&Technology,the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),the 111 Project;This work was also supported by the National Natural Science Foundation of China(No.31900988);the Natural Science Foundation of Jiangsu Province(No.SBK2019040088);Jiangsu Province Six Talent Peaks Project(No.SWYY-110).

摘　　要：Radiotherapy(RT)is a widely used way for cancer treatment.However,the efficiency of RT may come with various challenges such as low specificity,limitation by resistance,high dose and so on.Nitric oxide(NO)is known a very effective radiosensitizer of hypoxic tumor.However,NO cannot circulate in body with high concentration.Herein,an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy.Tert-Butyl nitrite,which is an efficient NO source,is coupled to Ag2S quantum dots(QDs).NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal effect.In addition,Ag is also a type of heavy metal that can benefit the RT therapy.We demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model.Furthermore,immunosuppressive tumor microenvironment is improved by our NO delivery system,significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy.100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery platforms.Our results suggest the promise of Ag2S NO delivery platforms for multifunctional cancer radioimmunotherapy.

关 键 词：NO delivery Radio sensitivity Multifunctional agent RADIOIMMUNOTHERAPY Drug delivery 

分 类 号：R730.51[医药卫生—肿瘤]