Effects of Fuzheng Huayu 319 recipe on liver fibrosis in chronic hepatitis B  

作　　者：LIU Ping LIU Cheng XU Lie-Ming Hu Yi-Yang XUE Hui-Ming LIU Cheng-Hai ZHANG Zhi-Qing 

机构地区：[1]不详

出　　处：《World Journal of Gastroenterology》1998年第4期76-81,共6页世界胃肠病学杂志（英文版）

基　　金：国家科学研究项目。

摘　　要：AIM To investigate clinic effects of Fuzheng Huayu 319 recipe (319 recipe) on liver fibrosis in chronic hepatitis B.METHODS Ninety-five patients with chronic hepatitis B were divide into the treated (63 cases) and control (32 cases) group, and orally administrated with 0.5g 319 capsule or 0.5g Dahuang Zhachong pill tid for 3 months, respectively. The liver functions and serological fibrotic markers were observed before and after treatment, 12 cases in the treated group were examined with liver biopsy.RESULTS Three hundreds nineteen recipe could remarkably decreased serum ALT level and total bilirubin and significantly improve serum albumin and A/G ratio. Its effects were better than Dahuang Zhachong pill. Before treatment, patients' serum monamine oxidase activities, tissue inhibitor of metalloproteinase (TIMP)-1, procollagen type Ⅲ and laminin were all higher than those of health peoples. These levels decreased remarkably after treatment, and urine hydroxyproline level increased significantly (P＜0.001-0.05). Compared with the control, the improvement in treated group was better than that in the control except TIMP-1. According to the scoring system for staging of chronic hepatitis, the fibrotic extents of 7 cases among 12 cases examined by liver biopsy decreased remarkably (1 case decreased by 3 scores, 5 by 2 scores, 1 by 1 score).CONCLUSION Fuzheng Huayu 319 recipe had good therapeutic effects on chronic hepatitis B, it could reverse the development of liver fibrosis to some extent. In general its effects were better than that of Dahuang Zhachong pill.

关 键 词：liver cirrhosis/therapy hepatitis B Fuzheng Huayu PROCOLLAGEN hyaluronic acid METALLOPROTEINASES HYDROXYPROLINE 

分 类 号：R512.62[医药卫生—内科学]