Studies on Hepatocyte-Targeting Magnetic Resonance Imaging Macromolecular Contrast Media  

作　　者：FU Yan jun ZHUO Ren xi 

机构地区：[1]Department of Chemistry,Wuhan University,Laboratory of Biomedical Polymer Materials of the State Education Commission of China,Wuhan,430072

出　　处：《Chemical Research in Chinese Universities》1997年第4期56-58,63,共7页高等学校化学研究(英文版)

摘　　要：DTPA was covalently conjugated to the copolymer of L lysine and L tyrosine, then transchelated with Gd EDTA,the resultant polymer chelates were further reacted with 6 O bromoacetyl D galactose or methyl lactobionyloxyacetate to give PLT(Gd DTPA) with galactose moiety as liver targeting group.These macromolecular MRI contrast agents were characterized by means of FT IR, ICP AES, elementary analyses and UV Vis spectrophotometry. Their in vitro relaxivity and liver targeting property in mice were also investigated.DTPA was covalently conjugated to the copolymer of L-lysine and L-tyrosine,then transchelated with Gd-EDTA,the resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose or methyl lactobionyloxyacetate to give PLT(Gd-DTPA)with galactose moiety as liver-targeting group.These macromolecular MRI contrast agents were characterized by means of FT-IR,ICP-AES,elementary analyses and UV-Vis spectrophotometry.Their in vitro relaxivity and liver targeting property in mice were also investigated.

关 键 词：MRI  macromolecular contrast media(MMCM) POLYLYSINE Hepatocyte  targeting RELAXIVITY BIODISTRIBUTION 

分 类 号：O482.531[理学—固体物理] Q517[理学—物理]