BIODISTRIBUTION

作品数：74被引量：114H指数：6
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相关作者：张晓云史彦斌倪京满赵鹏乔华更多>>
相关机构：上海交通大学兰州大学兰州大学第一医院中国工程物理研究院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划湖北省自然科学基金福建省自然科学基金更多>>
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Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives被引量：2
《Acta Pharmaceutica Sinica B》2024年第5期2006-2025,共20页Bingwen Ding Zhu Zhu Cong Guo Jiaxin Li Yong Gan Miaorong Yu 
This study was supported by the National Science Fund of Distinguished Young Scholars(No.82025032,China);the National Natural Science Foundation of China(No.82073773,China);the Key Research Program of Chinese Academy of Sciences(ZDBS-ZRKJZ-TLC005,China);Young Elite Scientists Sponsorship Program by CAST(No.2022QNRC001,China).
Diabetes,characterized by hyperglycemia,is a major cause of death and disability worldwide.Peptides,such as insulin and glucagon-like peptide-1(GLP-1)analogs,have shown promise as treatments for diabetes due to their ...
关键词：Oral peptides Diabetes Delivery platforms Insulin Glucagon-like peptide-1 BIODISTRIBUTION Biological barriers Targeted delivery 
Highly variable biodistribution of ^(68)Ga labeled somatostatin analogues ^(68)Ga-DOTA-NOC and ^(68)Ga-DOTA-TATE in neuroendocrine tumors: clinical implications for somatostatin receptor directed PET/CT被引量：1
《Hepatobiliary Surgery and Nutrition》2022年第5期654-661,共8页Monica Cheng Mark Tann 
Background:Somatostatin receptor(SSTR)-targeted positron emission tomography/computed tomography(PET/CT)imaging has risen to the forefront for neuroendocrine tumor(NET)detection and management,yet the variability of s...
关键词：Neuroendocrine tumors(NETs) liver PANCREAS gastrointestinal tract ^(68)Ga-DOTA PET imaging somatostatin receptors(SSTRs) targeted therapy 
Safety evaluation of nanodiamond-doxorubicin complexes in a Naïve Beagle canine model using hematologic,histological,and urine analysis被引量：3
《Nano Research》2022年第4期3356-3366,共11页Liping Wang Wenqiong Su Khan Zara Ahmad Xin Wang Ting Zhang Youyi Yu Edward Kai-Hua Chow Dean Ho Xianting Ding 
The work is partially funded by the National Natural Science Foundation of China(No.81871448);the National Key Research and Development Program of China(Nos.2017YFC0107603 and 2017ZX10203205-006-002);the Medical-Engineering Cross Foundation of Shanghai Jiao Tong University(Nos.YG2017QN52,ZH2018QNA54,and ZH2018QNA49).
While doxorubicin(DOX)is one of the most common chemotherapeutic drugs for treating cancer,use of DOX must be managed carefully due to dose-related toxicity.Nanodiamond(ND)drug delivery system conjugated with DOX(NDX)...
关键词：nanomedicine DOXORUBICIN NANODIAMONDS safety BIODISTRIBUTION 
Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application被引量：1
《Asian Journal of Pharmaceutical Sciences》2021年第6期704-737,共34页Preeti Kush Parveen Kumar Ranjit Singh Ajeet Kaushik 
Parveen Kumar acknowledges the department of science and technology(DST);New Delhi for the INSPIRE(Innovation in Science Pursuit for Inspired Research)-Faculty grant.
This review covers extensively the synthesis&surface modification,characterization,and application of magnetic nanoparticles.For biomedical applications,consideration should be given to factors such as design strategi...
关键词：MAGNETISM Synthesis Characterization Delivery Imaging BIODISTRIBUTION PHARMACOKINETIC 
Dendrimer-decorated nanogels:Efficient nanocarriers for biodistribution in vivo and chemotherapy of ovarian carcinoma被引量：3
《Bioactive Materials》2021年第10期3244-3253,共10页Xin Li Zhijun Ouyang Helin Li Chaolei Hu Pabitra Saha Lingxi Xing Xiangyang Shi Andrij Pich 
This research was financially supported by the Sino-German Center for Research Promotion(GZ1505),DFG(SFB 985,Functional Microgels and Microgel Systems),National Natural Science Foundation of China(81801704 and 81761148028);Science and Technology Commission of Shanghai Municipality(18520750400);Shanghai Sailing Program(18YF1415300)。
Nanomedicine has revolutionized disease theranostics by the accurate diagnosis and efficient therapy.Here,the PAMAM dendrimer decorated PVCL-GMA nanogels(NGs)were developed for favorable biodistribution in vivo and en...
关键词：NANOGELS DENDRIMER Surface charge Thermal/pH dual-responsiveness Drug delivery 
Manipulating endogenous exosome biodistribution for therapy被引量：2
《SmartMat》2021年第2期127-130,共4页Zhiwei Sun Yanyan Jiang Martina Stenzel 
Exosomes have been recognized as extracellular vesicles that mediate systemic information exchange and long-distance interactions between cells.1 Their functions are all highly reliant on systemic biological distribut...
关键词：EXOSOME ENDOGENOUS DISTRIBUTION 
The contribution of absorption of integral nanocrystals to enhancement of oral bioavailability of quercetin被引量：12
《Acta Pharmaceutica Sinica B》2021年第4期978-988,共11页Baode Shen Chengying Shen Weifeng Zhu Hailong Yuan 
supported by the National Natural Science Foundation of China(Nos.81803741 and 81873092)。
In this study,self-discriminating hybrid nanocrystals was utilized to explore the biological fate of quercetin hybrid nanocrystals(QT-HNCs)with diameter around 280 nm(QT-HNCs-280)and550 nm(QT-HNCs-550)following oral a...
关键词：NANOCRYSTALS Biological fate QUERCETIN PHARMACOKINETICS BIODISTRIBUTION Oral bioavailability CONTRIBUTION Drug delivery 
In vivo testing of mucus-permeating nanoparticles for oral insulin delivery using Caenorhabditis elegans as a model under hyperglycemic conditions被引量：2
《Acta Pharmaceutica Sinica B》2021年第4期989-1002,共14页Ana LMartínez-López Carlos JGonzález-Navarro Paula Aranaz JoséLVizmanos Juan MIrache 
supported by Postdoctoral Fellowship from the National Council for Science and Technology of Mexico(CONACyT,Grant No.291231,Mexico)。
The aim was to evaluate the potential of mucus-permeating nanoparticles for the oral administration of insulin.These nanocarriers,based on the coating of zein nanoparticles with a polymer conjugate containing PEG,disp...
关键词：NANOPARTICLES Oral delivery Mucus-permeating BIODISTRIBUTION INSULIN Caenorhabditis elegans ROS 
Graphene quantum dots: From efficient preparation to safe renal excretion被引量：1
《Nano Research》2021年第3期674-683,共10页Caroline Hadad JoséMiguel González-Domínguez Silvia Armelloni Deborah Mattinzoli Masami Ikehata Akcan Istif Adrian Ostric Francesco Cellesi Carlo Maria Alfieri Piergiorgio Messa Belén Ballesteros Tatiana Da Ros 
J.M.G.-D.acknowledges Spanish Ministry of Science,Innovation and Universities for his Juan de la Cierva Incorporación research contract(No.IJCI-2016-27789);This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement No.734834(INFUSION)and No.734381(CARBO-IMmap);from MIUR.ICN2 is supported by the Severo Ochoa program from Spanish MINECO(No.SEV-2017-0706).
Carbon nanomaterials offer excellent prospects as therapeutic agents,and among them,graphene quantum dots(GQDs)have gained considerable interest thanks to their aqueous solubility and intrinsic fluorescence,which enab...
关键词：graphene quantum dots PODOCYTES BIODISTRIBUTION uptake pathway renal clearance NANOCARRIER 
3D RNA nanocage for encapsulation and shielding of hydrophobic biomolecules to improve the in vivo biodistribution
《Nano Research》2020年第12期3241-3247,共7页Congcong Xu Kaiming Zhang Hongran Yin Zhefeng Li Alexey Krasnoslobodtsev Zhen Zheng Zhouxiang Ji Sijin Guo Shanshan Li Wah Chiu Peixuan Guo 
The research in P.G.’s lab was supported by NIH grants(Nos.R01EB019036,U01CA151648,and U01CA207946)to Peixuan Guo;The cryo-EM work was supported by NIH grant No.5941GM103832(W.C.)and Office of Naval Research grant No.N00014-20-1-2084(W.C.).P.G.’s Sylvan G.Frank Endowed Chair position in Pharmaceutics and Drug Delivery is funded by the CM Chen Foundation.The authors would like to thank the Nanoimaging Core Facility at UNMC for assistance with AFM imaging.The facility is in part supported by funds received from the Nebraska Research Initiative(NRI).The animal study protocol was approved by the Institutional Animal Care and Use Committee at The Ohio State University.The authors would like to thank Alyssa Castillo for help in sample preparation.
Ribonucleic acid(RNA)nanotechnology platforms have the potential of harboring therapeutics for in vivo delivery in disease treatment.However,the nonspecific interaction between the harbored hydrophobic drugs and cells...
关键词：ribonucleic acid(RNA)nanocage three-way junction(3WJ) ENCAPSULATION hydrophobic biomolecule RNA nanotechnology 
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