Manipulating endogenous exosome biodistribution for therapy  

作　　者：Zhiwei Sun Yanyan Jiang Martina Stenzel 

机构地区：[1]Key Laboratory for Liquid−Solid Structural Evolution and Processing of Materials,Ministry of Education,Shandong University,Jinan,China [2]School of Chemistry,Centre for Advanced Macromolecular Design(CAMD),University of New South Wales,Sydney,New South Wales,Australia

出　　处：《SmartMat》2021年第2期127-130,共4页智能材料（英文）

摘　　要：Exosomes have been recognized as extracellular vesicles that mediate systemic information exchange and long-distance interactions between cells.1 Their functions are all highly reliant on systemic biological distribution so that it is possible to promote the biological effects for therapy by accurately manipulating exosome biodistribution.However,given that the mechanisms for regulating the exosome biodistribution are unclear,it is challengeable to achieve the manipulation of exosome biodistribution by regulating molecular signals.Recently,Liu et al.2 reported a vesicle shuttle(VS),which was composed of a ferroferric oxide core,a silica shell,and a stimuli-cleavable poly(ethylene glycol)corona conjugated to two types of antibody(one against antigens on the exosomes of interest,and the other targeted to the recipient injured cells).2 They showed that the VS could effectively collect,transport,and release circulating exosomes to the designated areas inside the organism.

关 键 词：EXOSOME ENDOGENOUS DISTRIBUTION 

分 类 号：R73[医药卫生—肿瘤]