Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application  

作　　者：Preeti Kush Parveen Kumar Ranjit Singh Ajeet Kaushik 

机构地区：[1]School of Pharmacy,Adarsh Vijendra Institute of Pharmaceutical Sciences,Shobhit University Gangoh,Saharanpur,Uttar Pradesh 247341,India [2]Nanotechnology Division(H-1),CSIR-Central Scientific Instruments Organization,Chandigarh 160030,India [3]NanoBioTech Laboratory,Health System Engineering,Department of Natural Sciences,Florida Polytechnic University,Lakeland,FL 33805-8531,United States

出　　处：《Asian Journal of Pharmaceutical Sciences》2021年第6期704-737,共34页亚洲药物制剂科学（英文）

基　　金：Parveen Kumar acknowledges the department of science and technology(DST);New Delhi for the INSPIRE(Innovation in Science Pursuit for Inspired Research)-Faculty grant.

摘　　要：This review covers extensively the synthesis&surface modification,characterization,and application of magnetic nanoparticles.For biomedical applications,consideration should be given to factors such as design strategies,the synthesis process,coating,and surface passivation.The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration.Special insights have been provided on biodistribution,pharmacokinetics,and toxicity in a living system,which is imperative for their wider application in biology.These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging,for example,MRI-CT,MRI-PET.Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body.Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction,heat conduction,imaging,and magnetism.Surely,this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction.

关 键 词：MAGNETISM Synthesis Characterization Delivery Imaging BIODISTRIBUTION PHARMACOKINETIC 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]