THE EFFECT OF SEVERAL LEUKEMIA THERAPEUTIC DRUGS ON THE CALCIUM EQUILIBRIUM WITHIN THE K562 CELLS  

作　　者：陆承荣 刘亚宁 王辉 

机构地区：[1]Basic Laboratory, Xidiaoyutai Hospital, Beijing 100036 [2]Department of Haematology, Greatwall Hospital, Beijing 100853he Daunomycin, Cyclophosphamide, Cytarabine Hydrochloride and Vincrlstine Sulfale all are the drugs used in the therapy of leukemia. When the leukemia cell line, K562, were treated by them in vitro, a sharp decrease of intracellular free Ca2+ concentration could be found. The anti-cancer mechanisms of these drugs are inhibiting the DNA or RNA syntheses and Interrupting the mitoses of tumor cells. Our experiment suggested that beside the above behaviors, these anti-cancer drugs can also suppress the function of tumor cells by means of decreasing their intracellular Ca2+ levels.

出　　处：《Chinese Journal of Cancer Research》1993年第4期58-61,共4页中国癌症研究（英文版）

摘　　要：The Daunomycin, Cyclophosphamide, Cytarabine Hydrochloride and Vincrlstine Sulfale all are the drugs used in the therapy of leukemia. When the leukemia cell line, K562, were treated by them in vitro, a sharp decrease of intracellular free Ca2+ concentration could be found. The anti-cancer mechanisms of these drugs are inhibiting the DNA or RNA syntheses and Interrupting the mitoses of tumor cells. Our experiment suggested that beside the above behaviors, these anti-cancer drugs can also suppress the function of tumor cells by means of decreasing their intracellular Ca2+ levels.The Daunomycin, Cyclophosphamide, Cytarabine Hydrochloride and Vincrlstine Sulfale all are the drugs used in the therapy of leukemia. When the leukemia cell line, K562, were treated by them in vitro, a sharp decrease of intracellular free Ca2+ concentration could be found. The anti-cancer mechanisms of these drugs are inhibiting the DNA or RNA syntheses and Interrupting the mitoses of tumor cells. Our experiment suggested that beside the above behaviors, these anti-cancer drugs can also suppress the function of tumor cells by means of decreasing their intracellular Ca2+ levels.

关 键 词：DAUNOMYCIN Cyclophospamide Cytarablne Hydrochloride Vincristione sulfale LEUKEMIA CA2+ 

分 类 号：R73[医药卫生—肿瘤]