RELATIONSHIP BETWEEN HYPERSENSITIVITY TYPE I AND WHEEZING BY RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION  

作　　者：钱勇 李申生 齐家仪 

机构地区：[1]Shanghai Institute for Pediatric Research, SSMU, Shanghai

出　　处：《Medical Bulletin of Shanghai Jiaotong University》1990年第2期26-31,共6页上海交通大学学报（医学英文版）

摘　　要：We studied the RSV specific IgE antibody, histamine and basophil from infants with RSV bronchiolitis and found during the acute phase either the titers of RSV-IgE or the concentration of histamine increased significantly, the number of basophil and basophil degranulation in the presence of RSV antigen also increased. In vitro studies revealed hypersensitivity participates in the pathogenesis of RSV bronchiolitis. We also found that infants with RSV bronchiolitis, the RSV-IgE persisted for a long time presumably this plays an important role in recurrent wheezing after RSV infection for years.We studied the RSV specific IgE antibody, histamine and basophil from infants with RSV bronchiolitis and found during the acute phase either the titers of RSV-IgE or the concentration of histamine increased significantly, the number of basophil and basophil degranulation in the presence of RSV antigen also increased. In vitro studies revealed hypersensitivity participates in the pathogenesis of RSV bronchiolitis. We also found that infants with RSV bronchiolitis, the RSV-IgE persisted for a long time presumably this plays an important role in recurrent wheezing after RSV infection for years.

关 键 词：respiratory syncytial virus HYPERSENSITIVITY IMMUNOGLOBULIN E BASOPHIL HISTAMINE BRONCHIOLITIS 

分 类 号：R[医药卫生]