The Role of Dorsal Raphe Nucleus and 5-HT in the Electro-acupunctural Inhibition of the cAMP Induced ECoG Epileptiform Activities in Rabbits  

作　　者：娄之聪 陈水村 

机构地区：[1]Department of Physiolooy,First Military Medical University Guangzhou 510515

出　　处：《Journal of Medical Colleges of PLA(China)》1990年第2期151-156,共6页中国人民解放军军医大学学报（英文版）

摘　　要：Like electroacupuncture (EA),electrical stimulation of the dorsal raphe nucle-us (DRN)also inhibits the cAMP induced cortical epileptic waves and the EA inducedinhibition can be abolished or markedly reduced by iv cyproheptadine (CYP) or destruc-tion of DRN by electrolysis.The results suggest that 5-HT neurons in the DRN mayplay an important role in the EA inhibition of the generation of cAMP induced elec-trocorticogram (ECoG) epileptic waves.Like electroacupuncture (EA),electrical stimulation of the dorsal raphe nucle- us (DRN)also inhibits the cAMP induced cortical epileptic waves and the EA induced inhibition can be abolished or markedly reduced by iv cyproheptadine (CYP) or destruc- tion of DRN by electrolysis.The results suggest that 5-HT neurons in the DRN may play an important role in the EA inhibition of the generation of cAMP induced elec- trocorticogram (ECoG) epileptic waves.

关 键 词：epileptic waves ELECTROCORTICOGRAM CAMP electroacupuncture dorsal RAPHE nucleus CYPROHEPTADINE 

分 类 号：R[医药卫生]