The Effects of Human Fetal Liver Cells on Experimental Fulminant Hepatic Failure in Rats  

作　　者：郝飞 向居正 李奇芬 余曼英 

出　　处：《Journal of Medical Colleges of PLA(China)》1990年第3期246-250,共5页中国人民解放军军医大学学报（英文版）

摘　　要：The beneficial dffects of human fetal liver cells on the D-galactosamine-inducedfulminant hepatic failure were observed in rats and the mechanisms of the effects investi-gated.The survival rate of the rats intraperitoneally injected with liver cell suspensionand cytosol was 47.37% and 42.11% respectively which was significantly higher than5.26% of the controls（P【0.05）.There was no statistical significance between the differ-ence of the survival rates due to two preparations.The administration of cytosol two hours before the intoduction of D-galactosamine re-sulted in a significant lowering of the plasma level of endotoxin and hepaticmalondialdehyde in rats and a marked increase of ³H-thymindinc incorporation intohepatic DNA(DPM/OD₂₆₀)as compared with the parameters of the controls.These re-sults suggest that there might be some biological active substance in human fetal liver cellswhich is responsible for thc effects to increase the survival rate.The beneficial dffects of human fetal liver cells on the D-galactosamine-induced fulminant hepatic failure were observed in rats and the mechanisms of the effects investi- gated.The survival rate of the rats intraperitoneally injected with liver cell suspension and cytosol was 47.37% and 42.11% respectively which was significantly higher than 5.26% of the controls(P<0.05).There was no statistical significance between the differ- ence of the survival rates due to two preparations. The administration of cytosol two hours before the intoduction of D-galactosamine re- sulted in a significant lowering of the plasma level of endotoxin and hepatic malondialdehyde in rats and a marked increase of ~3H-thymindinc incorporation into hepatic DNA(DPM/OD_(260))as compared with the parameters of the controls.These re- sults suggest that there might be some biological active substance in human fetal liver cells which is responsible for thc effects to increase the survival rate.

关 键 词：liver diseases GALACTOSAMINE CYTOSOL MALONDIALDEHYDE ENDOTOXIN HEPATIC failure ~3H-thymidine 

分 类 号：R[医药卫生]