supported by a grant from the Science and Technology Research Foundation of Educational Committee,Heilongjiang Province,China(12531294)
BACKGROUND: Acute liver failure (ALF) is a severe and life- threatening clinical syndrome resulting in a high mortality and extremely poor prognosis. Recently, a water-soluble CO-releas- ing molecule (CORM-3) has...
AIM: To investigate the effects of broccoli sprout extract(BSEx) on liver gene expression and acute liver injury in the rat.METHODS: First, the effects of BSEx on liver gene expression were examined. Male rats were di...
The project supported by the National Natural Science Foundation of China(81160048);the Science and Technology Development Fund,Macao S.A.R(FDCT)(021/2012/A1);the Research Fund of University of Macao(MRG007/CXP/2013/ICMS)
OBJECTIVE Isofuranodiene(ISO)is a natural product isolated in Chinese herb.Our recent results showed anticancer effect in vitro.In this study,we investigated its live protective effect with a Dgalactosamine/lipopolysa...
carried out as a Part of doctoral studies through the general research funding of the University
Objective:To investigate the effect of lycopene on lipoprotein metabolism during D-galactosamine/lipopolysacchoride(D-Gal/LPS)induced hepatitis in experimentul rats.Methods:The efficacy of lycopene was validated durin...
supported by grants from the Deason Foundation (Sandra and Eugene Davenport,Mayo ClinicCD CRT-II);the AHA (0655589B);the NIH (R01NS05164601A2);the Uehara Memorial Foundation (200940051)
BACKGROUND:A reliable model of fulminant liver failure (FLF) is urgently required in this research field.This study aimed to develop a murine FLF model.METHODS:We used three groups of male C57BL/6 mice:control,with az...
Supported by The National Institute on Alcohol Abuse and Alcoholism;the Department of Veterans Affairs
The asialoglycoprotein (ASGP) receptor is a wellcharacterized hepatic receptor that is recycled via the common cellular process of receptor-mediated endocytosis (RME). The RME process plays an integral part in the...
Objective To observe the role of superantigen staphylococcal enterotoxin B(SEB) andD - galactosamine (D - GalN) on Balb/c mouse hepatocytes and its mechanism. Methods After Balb/c mice wereinjected intraperitoneally w...
The changes of the levels of LTC4, PGI2 and TXA2 in the liver tissue in SD rats with GaIN/LPS-induced acute liver injury was studied with radioimmunoassay (RIA). As a result,12h after the administration of GaIN/LPS, s...