ELECTROPHYSIOLOGICAL EVIDENCE FOR HYPERALGESIA IN THE PERIPHERAL NEUROPATHY  

作　　者：谢益宽 肖文华 

机构地区：[1]Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100730, PRC

出　　处：《Science China Chemistry》1990年第6期663-672,共10页中国科学（化学英文版）

基　　金：This work was supported by Ministry of Public Health, China.

摘　　要：A peripheral neuropathy was produced in adult rats by placing loosely constrained ligature around the common sciatic nerve. At the ligature region of the nerve, demyelination developed. The postoperative behavior of these rats indicated that hyperalgesia and allodynia were produced. The electrical activity pattern of the damaged fibers was remarkably different from those of normal nerves: there were some abnormal spontaneous afferent firings from the injured fibers; multi-impulse responses of C-fiber to single shock was recorded; a lasting firing was elicited after the injured region was gently pressed or by oil drops at 40℃; an antidromic electric stimulus to the injured region, stimulations of L, sympathetic ganglion or systemic administration of noradrenalin, all caused an increase in on-goingspontaneous discharges of the injured fibers or brought the silent fibers into firing. Stimulation of the dorsal roots of the sciatic nerve produced no effect on their activities or caused a pause of the on-going discharges of them. Pheutolamine, an alpha receptor blocker, ceased the abnormal firing, but did not affect the normal fiber firings. It is hypothesized that noradrenalin released by the sympathetic nerve would be an important factor responsible for both hyperalgesia and allodynia following injury of peripheral nerve.A peripheral neuropathy was produced in adult rats by placing loosely constrained ligature around the common sciatic nerve. At the ligature region of the nerve, demyelination developed. The postoperative behavior of these rats indicated that hyperalgesia and allodynia were produced. The electrical activity pattern of the damaged fibers was remarkably different from those of normal nerves: there were some abnormal spontaneous afferent firings from the injured fibers; multi-impulse responses of C-fiber to single shock was recorded; a lasting firing was elicited after the injured region was gently pressed or by oil drops at 40℃; an antidromic electric stimulus to the injured region, stimulations of L, sympathetic ganglion or systemic administration of noradrenalin, all caused an increase in on-goingspontaneous discharges of the injured fibers or brought the silent fibers into firing. Stimulation of the dorsal roots of the sciatic nerve produced no effect on their activities or caused a pause of the

关 键 词：NERVE INJURY HYPERALGESIA PERIPHERAL NEUROPATHY noradrenalin. 

分 类 号：O6[理学—化学]