实验性动脉粥样硬化模型贵州小型香猪血浆生物活性物质的观察  

An observation on the plasma of biological active substances in experimental atherosclerosis model Guizhou minipigs

作　　者：孙爱励[1] 王辅才[1] 胡晓东[1] 孙纪新[1] 许顺江[1] 

机构地区：[1]河北省医学科学院实验医学研究所

出　　处：《实验动物与比较医学》1990年第3期142-143,141,共3页Laboratory Animal and Comparative Medicine

摘　　要：本文报告了高胆固醇喂养诱发小型猪—贵州香猪、动脉粥样硬化(AS)后,血浆心钠素、醛固酮、皮质醇和环磷酸腺苷的变化。作者认为,实验性AS与血浆心钠素水平无关,而与肾上腺皮质激素及环核苷酸的变化有关,尤以后者为主。In order to understand the possibJe effects of a new experimental atherosclerosis modcl-Guizhou minipigs, the levels of Atrial Natriuretic Factor (ANF), Aldosterone (Ald), Cortisol and cyclic AMP(cAMP) in plasma were evaluated. These minipigs were fed by cholesterol and egg yolk of high dosage for 24-30 weeks. It was found that the level of ANF hadn't any change, level of Ald increased markedly, levels of Cortisol and cAMP decreased significantly. The results indicated that level of ANF was unaffected but level of suprarenal cortex hormones and cyclic neucleotides were correlated with atherosclerosis. The latter may be more important. We recommend that Guizhou minipigs are perfecter lactation animal on the research of atherosclerosis.

关 键 词：血浆心钠素 环核苷酸 环磷酸腺苷 小型猪 生物活性物质 实验动物 非人灵长类 舒张血管 分离血浆 脂蛋白水平 

分 类 号：R[医药卫生] Q95[生物学—动物学]