Morphine attenuates frustration-like behavior induced by sucrose reward deprivation in rats  

作　　者：Qing Liu Wangjun Qin Min Zhang Yanting Wang Li Jing Junxu Li Jianhui Liang 

机构地区：[1]National Institute on Drug Dependence, Peking University, Beijing 100191, China [2]Department of Physiology, Tianjin Medical University, Tianjin 300070, China [3]Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA 14214

出　　处：《Neural Regeneration Research》2011年第28期2211-2216,共6页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China,No.30870894;the National Basic Research Program of China,No.2009CB522000;National Key Technology R&D Program in the 12th Five-Year Plan of China,No.2011BAK04B08

摘　　要：In this study, a T-maze-based frustration model in rats was established using sucrose-reward deprivation, The results revealed that rats maintained a 75% preference for the sucrose-reward arm in the reward phase. During the sucrose-deprivation frustration phase, both the preference for the sucrose-deprivation arm （62.5%） and time spent waiting in the sucrose-deprivation arm decreased. Acute injection of morphine increased the preference in a dose-dependent fashion, and prolonged the waiting duration in the sucrose-deprivation arm. These findings indicate that morphine specifically inhibited the frustration response induced by sucrose reward deprivation. To further elucidate the pharmacological mechanisms involved, the opioid receptor antagonist naloxone was given to model rats prior to the injection of morphine. The results revealed that naloxone administration markedly attenuated the anti-frustration-like effects of 3 mg/kg morphine treatment. These findings suggest that morphine attenuates the frustration-like response to reward deprivation in rats through the opioid receptor.In this study, a T-maze-based frustration model in rats was established using sucrose-reward deprivation, The results revealed that rats maintained a 75% preference for the sucrose-reward arm in the reward phase. During the sucrose-deprivation frustration phase, both the preference for the sucrose-deprivation arm （62.5%） and time spent waiting in the sucrose-deprivation arm decreased. Acute injection of morphine increased the preference in a dose-dependent fashion, and prolonged the waiting duration in the sucrose-deprivation arm. These findings indicate that morphine specifically inhibited the frustration response induced by sucrose reward deprivation. To further elucidate the pharmacological mechanisms involved, the opioid receptor antagonist naloxone was given to model rats prior to the injection of morphine. The results revealed that naloxone administration markedly attenuated the anti-frustration-like effects of 3 mg/kg morphine treatment. These findings suggest that morphine attenuates the frustration-like response to reward deprivation in rats through the opioid receptor.

关 键 词：FRUSTRATION MORPHINE sucrose reward deprivation T-MAZE naloxone 

分 类 号：Q959.837[生物学—动物学] TS245.1[轻工技术与工程—制糖工程]