塞莱昔布对乳腺癌大鼠肝肾功能的影响  

Effect of celecoxib on hepatic and renal functions in rats with mammary carcinoma

作　　者：姚雨石[1] 钱跃清[2] 于忠和[2] 

机构地区：[1]北京军区总医院生物治疗中心,100700 [2]北京军区总医院肿瘤科,100700

出　　处：《武警医学》2011年第11期973-975,978,共4页Medical Journal of the Chinese People's Armed Police Force

基　　金：首都医学科学发展基金(2002-3025)

摘　　要：目的评价预防性应用选择性环氧化酶-2抑制药塞莱昔布对化学诱导乳腺癌大鼠肝、肾功能的影响。方法雌性Sprague Dawley大鼠(SD大鼠)给予二甲基苯并蒽(7,12 dimethlbenz anthracene,DMBA)一次性灌胃诱发乳腺肿瘤过程中,连续给予不同剂量塞莱昔布,观察短期和长期应用不同剂量塞莱昔布对大鼠肝、肾功能的影响。结果塞莱昔布给药第4周时各组大鼠肝、肾功能差异无统计学意义,第17周时各组大鼠肝功能差异无统计学意义,而塞莱昔布大、中剂量组大鼠血清肌酐水平较模型对照组显著升高,小剂量组大鼠血清肌酐水平无显著改变(造模第17周血清肌酐水平:塞莱昔布50 mg/kg组P>0.05,100 mg/kg组P<0.01,150 mg/kg组P<0.01)。结论预防性应用塞莱昔布对DMBA诱导乳腺肿瘤大鼠有较好的安全性,但塞莱昔布大剂量长期应用对肾功能有一定影响,其临床应用安全性值得进一步探索。Objective To evaluate the effect of celecoxib, a selective cyclooxygenase -2 inhibitor, on the hepatic and renal functions of rats with chemically induced mammary carcinoma. Methods A single dose of 7,12 dimethgylbenz anthracene was administered i.g. into female SD rats to induce mammary carcinoma, during which celecoxib was given at various doses. Hepatic and renal functions were determined and statistically analyzed in rats receiving various doses of celecoxib. Results Four weeks into the experiment, hepatic and renal functions in none of the groups were significantly different. The same was true of hepatic functions on week 17, when serum ereatinine levels in 100 mg/kg and 150 mg/kg eelecoxib groups were significantly different, compared with those in model control group （ P 〈 0.01 ）. However, the serum creatinine level in 50 mg,/kg eelecoxib group was not significantly different from that in model control group （ P 〉 0.05 ）. Conclusions Prophylactic administration of celecoxib in rats with DMBA - induced breast tumors is safe, though prolonged administration of eelecoxib at high doses results in impaired renal function. Further studies are required to validate its safety profiles in clinical application.

关 键 词：塞莱昔布 DMBA 乳腺肿瘤 大鼠 肝肾功能 

分 类 号：R151.2[医药卫生—营养与食品卫生学]