Xuebijing alters tumor necrosis factor-alpha, interleukin-1beta and p38 mitogen activated protein kinase content in a rat model of cardiac arrest following cardiopulmonary resuscitation  

作　　者：Haifeng Li Mingli Sun Yaxin Yu Xiaoliang Liu 

机构地区：[1]Emernenc.v Medicine. Second Branch of First Hosoital of Jilin University, Chanclchun 130031, Jilin Province, China

出　　处：《Neural Regeneration Research》2011年第33期2573-2576,共4页中国神经再生研究（英文版）

基　　金：a grant from the Science and Technology Department of Jilin Province,No. 200705172

摘　　要：We established a rat model of cardiac arrest by clamping the endotracheal tube of adult rats at expiration. Twenty-four hours after cardiopulmonary resuscitation, nerve cell injury and expression of tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase content were increased. Rats injected with Xuebijing, a Chinese herb compound preparation, exhibited normal cellular structure and morphology, dense neuronal cytoplasm, and decreased tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase expression at 24 hours following cardiopulmonary resuscitation. These data suggest that Xuebijing can attenuate neuronal injury induced by hypoxia and reperfusion during cardiopulmonary resuscitation.We established a rat model of cardiac arrest by clamping the endotracheal tube of adult rats at expiration. Twenty-four hours after cardiopulmonary resuscitation, nerve cell injury and expression of tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase content were increased. Rats injected with Xuebijing, a Chinese herb compound preparation, exhibited normal cellular structure and morphology, dense neuronal cytoplasm, and decreased tumor necrosis factor-α, interleukin-1β, and p38 mitogen activated protein kinase expression at 24 hours following cardiopulmonary resuscitation. These data suggest that Xuebijing can attenuate neuronal injury induced by hypoxia and reperfusion during cardiopulmonary resuscitation.

关 键 词：cardiac arrest brain tumor necrosis factor-α INTERLEUKIN-1Β p38 mitogen activated protein kinase XUEBIJING cardiopulmonary resuscitation 

分 类 号：Q555.7[生物学—生物化学] Q786