Hedgehog信号通路与肿瘤发生机制的研究进展  

Hedgehog signal pathway and the mechanism of tumorigenesis

作　　者：梅怡[1] 殷佩浩[1] 史永照[1] 

机构地区：[1]上海中医药大学附属普陀医院普外科,上海200025

出　　处：《国际外科学杂志》2011年第11期755-757,共3页International Journal of Surgery

基　　金：上海市卫生局中医药科研基金（No.2010QL050B）

摘　　要：恶性肿瘤是危害人类健康的主要疾病之一，确切的发病机制尚不清楚，但可以肯定的是，其形成具有多因素、多步骤的特点，涉及一系列原癌基因异常的激活以及抑癌基因突变导致的失活，从而引起一些信号转导通路的异常。近年来，通过对Hedgehog（Hh）信号通路的研究显示，Hh基因编码一系列分泌型信号蛋白，对胚胎发育过程中的细胞分化和增生具有重要作用，Hh信号通路的异常活化在恶性肿瘤的发生发展过程中起了重要作用。信号蛋白Hh的信号通路至少包括：patched（Ptch）、smoothened（Smo）、fused（Fu）、suppressor of fused（SuFu），costaI-2（Cos-2）以及cubitus interruptus（Ci）等。本文就Hh基因家族的功能及其与多种人类恶性肿瘤发生相关的机制作一简要综述。As one of the most major disease, malignant tumor is harmful to human health. Althought it＇ s exact pathogenesis is still not clear, it is certainly that the formation of cancer is typical of containing many factors and having gone through many steps. Resulting from the abnormal activation of a series of proto- onco- gene as well as the inactivation caused by many anti-oncogene mutation, some signal pathways work abnor- mally. In recent years, the study of Hedgehog （ Hh）, as the signal pathway, shows that Hh encodes a series of secreted signaling protein, having an important effect on the differentiation and proliferation of cells in the process of embryogenesis. The occurrence of abnormal activation of Hh signaling pathway plays a significant role in the process of tumorigenesis. Signal paths of Hh signaling protein include as much as following at least： patched（Ptch）, smoothened （Smo）, fused （Fu）, suppressor of fused （SuFu）, costaI-2 （Cos）-2 and cubitus interruptus （Ci） and so on. In this paper, the function of Hh genetic family and the mechanism of its relation to many kinds of human cancers will be givien a brief overview.

关 键 词：HEDGEHOG信号通路 PATCHED SMOOTHENED GLI 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]