2′-脱氧-2′-氟-2′-尿嘧啶-3′,4′-O-异亚丙基-L-阿拉伯糖甲苷的合成  

Synthesis of Methyl 2'-Deoxy-2'-fluoro-2'-uracil-3', 4'-O-isopropylidene-L-arabinoside

作　　者：马灵台[1] 杨宪斌[1] 董领娇 张礼和[1] 

机构地区：[1]北京医科大学药学院,北京100083

出　　处：《有机化学》1990年第3期233-236,共4页Chinese Journal of Organic Chemistry

摘　　要：目前,氟代糖和氟代糖苷在抗肿瘤和抗病毒的研究方面已引起人们的广泛兴趣。Methyl 2-deoxy-2, 2-difluoro-3, 4-O-isopropylidene-L-erythro-pentopyranoside(9) wasreacted with trimethylsilylated uracil to give 2'-fluorinated uracil isonucleoside. The configur-ation and conformation of the primary product was identified with IR, UV, ^(19)F NMR, 2DPMR (COSY, NOESY) and MS.

关 键 词：偕二氟代数 异核苷 三甲基硅烷化 

分 类 号：R914.5[医药卫生—药物化学]