Difluoromethylation of O-, S-, N-, C-Nucleophiles Using Difluoromethyltri（n-butyl）ammonium Chloride as a New Difluorocarbene Source  

作　　者：王飞 黄维洲 胡金波 

机构地区：[1]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2011年第12期2717-2721,共5页中国化学（英文版）

基　　金：Projrct supportted by the National Natural Science Foundation of China （Nos. 20772144, 20825209, 20832008） and the Chinese Academy of Sciences （Hundreds-Talent Program and Knowledge Innovation Program）.

摘　　要：Difluoromethyltri（n-butyl）ammonium chloride 1 was found to be an effective difluorocarbene reagent for O-, S-, N-, C-difluoromethylation under basic conditions. It is particularly remarkable that, when only 1.2 equivalent of reagent 1 was used, the difluoromethylated products were obtained in moderate to excellent yields.Difluoromethyltri（n-butyl）ammonium chloride 1 was found to be an effective difluorocarbene reagent for O-, S-, N-, C-difluoromethylation under basic conditions. It is particularly remarkable that, when only 1.2 equivalent of reagent 1 was used, the difluoromethylated products were obtained in moderate to excellent yields.

关 键 词：DIFLUOROCARBENE CF2H group DIFLUOROMETHYLATION difluoromethyltri（n-butyl）ammonium chloride 

分 类 号：TQ113.72[化学工程—无机化工] O623.624[理学—有机化学]