奥扎格雷钠在转化糖等三种注射液中的稳定性考察  

Stability of ozagrel sodium for injections in invertose injection, fructose injection and xylitol injection

作　　者：宋士卒[1] 王兰香[2] 韩静文[3] 

机构地区：[1]安徽医科大学第一附属医院药剂科国家中医药管理局中药化学三级实验室,安徽合肥230022 [2]安徽省泾县中医院,安徽泾县242500 [3]安徽医科大学药学院,安徽合肥230022

出　　处：《安徽医药》2011年第12期1603-1604,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的考察注射用奥扎格雷钠在转化糖等三种注射液中的稳定性。方法采用高效液相色谱(HPLC)法测定6 h内奥扎格雷钠在转化糖等三种注射液中的含量,并考察配伍液在不同时间的外观、pH值变化。结果奥扎格雷钠在转化糖等三种注射液中中的含量6 h内无明显变化,各配伍液的外观和PH值无明显变化。结论室温6 h内,注射用奥扎格雷钠可以在转化糖等三种注射液中配伍使用。Aim To study the stability of ozagrel sodium for injections in invertose injection,fructose injection and xylitol injection.Methods The contents of ozagrel sodium for injections were determined by HPLC,meanwhile their changes in the appearances and the pH values were observed.Results The contents of ozagrel sodium for injections were stable within 6 hours,and the mixed solutions and their pH values were stable on the whole.Conclusion Ozagrel sodium can be mixed with invertose injection,fructose injection or xylitol injection for clinical use.

关 键 词：奥扎格雷钠 果糖 转化糖 木糖醇 稳定性 

分 类 号：R927.2[医药卫生—药学]