肉毒杆菌毒素A治疗先天性眼球震颤疗效的眼震电图分析  

Analysis of the treatment effect of botulinum toxin A on congenitalnystagmus by electronystagmogram

作　　者：邓宏伟[1] 杨景存[1] 曹木荣[1] 

机构地区：[1]河南医科大学第一附属医院眼科

出　　处：《眼科研究》1999年第6期481-484,共4页Chinese Ophthalmic Research

摘　　要：目的　观察肉毒杆菌毒素Ａ（ＢＴＡ） 治疗先天性眼球震颤（ＣＮ） 的效果，并进一步探讨其应用规律。 方法　对２２ 例先天眼震患者，用兰州生物制品所生产的ＢＴＡ，以眼震图（ＥＮＧ） 检查注射前与注射后１ 周，１ ，３ ，６ 月的近、远距离眼震情况，各组进行统计学处理，并比较统计学差异。 结果　注药后１ 周与注药前相比近距离原眼位眼震振幅降低有明显统计学差异（ Ｐ＜ ０ ．０５） ；注药后１ 月与注药前相比，除近距离原眼位震频降低无明显统计学差异（ Ｐ＞ ０ ．０５） 外，其它远、近距离原眼位的各眼震参数降低均有明显统计学差异（ Ｐ＜ ０ ．０５） ；注药后３ ，６ 月与注药前相比近、远距离原眼位振幅降低有明显统计学差异（ Ｐ＜ ０ ．０５） ；最小震强位置注药后１ 周，１ ，３ ，６ 月与注药前相比虽无显著差异，但从频数分布图中可见最小震强出现的位置有向原眼位集中的趋势。 结论　该方法治疗先天性眼球震颤可使近、远距离原眼位眼震有所减轻，代偿头位有所改善。注药后１ 月疗效最显著，注药后３ 月疗效开始回退，但可重复注药。该方法治疗先天性眼球震颤有明显效果。ObjectiveTo investigate the effect of injecting botulinum toxin A(BTA) in patients with congenital nystagmus(CN).Methods22 CN patients were injected BTA,which was produced by Lan Zhou Biology Institute,into extraocular muscles directly.The changes of ocular nystagmus were measured by electronystagmogram (ENG) before injection and after injection of one week,one month,three months,and half a year.Statistic analysis was made in each group.ResultsThere was a significant difference between one week after injection group and pre injection group in amplitude on the primary eye position of close quarters ( P<0.05 ).There was significant difference between one month after injection group and pre injection group in all of the nystagmus data,except the frequency on the primary position of eyes in far distance ( P<0.05 ).In the three month and half a year after injection,the amplitudes of nystagmus in near and far distance primary position of eyes had significant differences comparing with the pre injection group ( P<0.05 ).The lowest intensity position although changed with no significant difference after injection of BTA,it can be seen that the position has the tendency of nearing the primary eye position by the analytic map of frequency table.ConclusionThis treatment on CN is effective in reducing nystagmus in the primary eye position.The most effective period was on one month after injection.On half a year,the effect reduced comparing with that of one month.The compensatory head postures are corrected in some degree.BTA injection has a good effect on the treatment of patients with CN.It is a new method for the clinical treatment of CN.

关 键 词：肉毒杆菌毒素A 先天性眼球震颤 眼震电图 

分 类 号：R777.460.5[医药卫生—眼科] R770.43[医药卫生—临床医学]