牛磺酸抗运动疲劳的效果观察  

Study on the anti-fatigue effect by taurine

作　　者：徐晓平[1] 张国顺[1] 王玉兰[1] 张学军[1] 田国华[1] 马宁[1] 

机构地区：[1]河北联合大学附属医院消化内科,唐山063000

出　　处：《中国综合临床》2011年第12期1271-1273,共3页Clinical Medicine of China

基　　金：基金项目：唐山市科技攻关项目（081302010）

摘　　要：目的研究牛磺酸对小鼠的抗运动疲劳效果。方法随机将鼠分成对照组和牛磺酸高、低2个剂量组，剂量分别为10．0g／L和2．5g／L，对照组给予等剂量生理盐水灌胃，实验周期30d。评价指标包括小鼠负重游泳时间、肝糖原、尿素氮和血乳酸。结果与对照组比较，高、低2个剂量组均能显著提高小鼠负重游泳时间以及肝糖原的质量浓度[高剂量组小鼠负重游泳时间为（380．9±65．5）s、低剂量组为（226．0±44．8）S、对照组为（175．7±24．4）s，F值为59．2，P〈0．05；肝糖原质量浓度分别为：（21．85±4．21）、（13．26±2．16）、（7．13±1．34）mg／g，F值为81．4，P〈0．05]；且能显著降低运动后血乳酸和尿素氮的浓度[血乳酸浓度分别为：（5．08±0．55）、（6．00±0．58）、（7．94±0．64）mmol／L，F值为73．2，P〈0．05；尿素氮浓度分别为：（6．18±0．70）、（7．33±0．65）、（8．21±0．87）mmol／L，F值为22．4，P〈0．05]。结论牛磺酸具有良好的抗运动疲劳作用。Objective To evaluate the anti-fatigue effect by taurine in mice. Methods Mice were randomly divided into three groups, two groups were given taurine at dose of 10. 0 g/L and 2. 5 g/L respectively, and the control group was given physiological Saline. After 30 days of intervention, the swimming test was carried out,the liver glycogen, serum BUN and Lactic acid were also measured. Results Both high taurine and low taurine prolonged the swimming time significantly comparing with ＇the control group （ [ 380. 9 ± 65.5 ] s vs [ 226. 0 ± 44. 8 ] s vs [ 175.7 ± 24.4 ] s, P 〈 0.05 ）. Liver glycogen also increased significantly, they were （21.85 ±4. 21 ）, （ 13.26 ±2. 16） （7.13 ± 1.34） mg/g in high,low taurine and control group respectively. The level of BUN and LAC were decreased significantly in taurine groups （ P 〈 0. 05 ）. Conclusion Taurine may has the anti-fatigue effect to some extent.

关 键 词：牛磺酸 负重游泳试验 肝糖原 乳酸 尿素氮 

分 类 号：R285.5[医药卫生—中药学]