Effects of Estradiol on 5-HTsA and 5-HT2c Receptor Immunolabeling in Rat Hippocampus  

作　　者：Laura Cristina Berumen Marco Antonio Sainchez-Ramos Martin Garcla-Servin Ataulfo Martinez-Torres Angelina Rodriguez Guadalupe Garcla-Alcocer 

机构地区：[1]Facultad de Quimica, Universidad A utonoma de Querotaro, Centro Universitario, Queretaro 76010, Mexico [2]Facultad de Ciencias Naturales, Universidad Autonoma de Queretaro, Campus Juriquilla, Juriquilla Queretaro 76230, Mexico [3]Department of Cellular and Molecular Neurobiology, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico Campus Juriquilla, Juriquilla Queretaro 76230, Mexico

出　　处：《Journal of Life Sciences》2011年第11期884-889,共6页生命科学（英文版）

摘　　要：Steroid hormones participate in the modulation of serotonergic transmission, including the regulation of synthetic and metabolic enzyme production, as well as receptor and transporter activity. The changes of 5-HT5A and 5-HT2c immunolabeling induced by steroids in the hippocampus ofovariectomized rats were studied in this work. Densitometric analysis in rat hippocampi were carried out for adjacent brain coronal immunolabeled sections after treatment with subcutaneous injections of vehicle, estradiol, progesterone or the combination of both steroids in ovariectomized rats. Exposure to estradiol and the combination of estradiol and progesterone significantly reduced the 5-HT5A-like immunosignal in the CA 1 region while progesterone did not induce changes. On the other hand, exposure to the combination of estradiol and progesterone or estradiol alone increased the 5-HT2c immunosignal in the same region. These results indicate that estradiol is involved in the discrete regulation of serotonin receptors 5-HT5A and 5-HT2c in rat hippocampus.

关 键 词：Serotonin receptor 5-HTsA 5-HT2c HIPPOCAMPUS ESTRADIOL PROGESTERONE 

分 类 号：Q579.13[生物学—生物化学] S945.26[农业科学—水产养殖]