妊娠中期超声筛查胎儿Turner综合征的临床价值  

Clinical Value of Ultrasonography in Screening Turner Syndrome(45,X) During the Second Trimester

作　　者：潘玉萍[1] 蔡爱露[1] 王晓光[1] 韩冰[1] 王冰[1] 王丽芝[2] 王岳平[3] 

机构地区：[1]中国医科大学附属盛京医院超声科,沈阳市110004 [2]中国医科大学附属盛京医院妇产科,沈阳市110004 [3]中国医科大学附属盛京医院遗传室,沈阳市110004

出　　处：《中国超声医学杂志》2012年第1期68-71,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家科技支撑计划(No.2006BAI05A04)

摘　　要：目的探讨妊娠中期超声筛查胎儿Turner综合征(45,X)的临床价值。方法在妊娠中期对有产前诊断指征的3 948例孕妇行羊水穿刺术检查染色体核型,比较不同指征孕妇Turner综合征(45,X)的检出率,并分析Turner综合征(45,X)与超声异常的关系。结果接受羊水穿刺的3 948例孕妇中,检出Turner综合征8例,Turner综合征检出率0.20%,3 948例孕妇中超声异常1 20例,检出Turner综合征(45,X)2例,检出率1.67%。超声异常组Turner综合征(45,X)检出率(1.67%)明显高于高龄孕妇组(0.11%)、唐氏高危组(0.06%),P<0.05。结论妊娠中期超声筛查胎儿对早期发现Turner综合征(45,X)有很大的价值。Objective To investigate the clinical value of ultrasonography in screening Turner syndrome（45,X） during the second trimester. Methods Amniocentesis were performed on 3 948 pregnant women with indications for prenatal diagnosis to detect karyotype of the fetus during second trimester, The detection rate of Turner syndrome（45, X） was compared in pregnant women of different indications. To analyze the relationship between the ultrasonography abnormalities and Turner syndrome（45,X）. Results In chromosomal k^ryotypes analysis of 3 948 pregnant women by amniocentesis,8 Turner syndrome were detected, the detection rate of Turner syndrome was 0. 20%, There were 120 in 3 948 pregnant women with ultrasonography abnormalities. 2 Turner syndrome（45,X） were found of them and the detection rate of Turner syndrome （45,X）was 1.67%, the detection rate of Turner syndrome （45,X）detected by ultrasound （ 1.67 % ） was higher than advanced age group（0.11% ）, the Down＇ s syndrome high risk group（0.06% ） （P〈 0.05）. Conclusions During the second trimester, ultrasonography has great value in screening Turner syndrome （45,X）.

关 键 词：羊膜腔穿刺术 核型分析 超声 TURNER综合征 

分 类 号：R714.5[医药卫生—妇产科学] R445.1[医药卫生—临床医学]