乳酸菌生理功能的系统解析与代谢调控  

Systematic analysis and metabolic regulation of physiological functions for lactic acid bacteria——A review

作　　者：吴重德[1,2] 张娟[1,2] 刘立明[1,2] 

机构地区：[1]江南大学食品科学与技术国家重点实验室,无锡214122 [2]江南大学工业生物技术教育部重点实验室,无锡214122

出　　处：《微生物学报》2012年第1期22-29,共8页Acta Microbiologica Sinica

基　　金：国家自然科学基金重点项目(20836003);国家"973项目"(2007CB714303);江苏高校优势学科建设工程资助项目~~

摘　　要：作为工业化的细胞工厂,乳酸菌广泛应用于食品、农业和医药等行业。然而在乳酸菌的工业生产中以及作为益生菌在人体胃肠道系统中都会面临多种环境胁迫,这些胁迫环境严重影响乳酸菌的生理功能,从而影响食品微生物制造的效率。近年来,随着代谢工程和系统生物学的发展,为乳酸菌生理功能的改造带来了前所未有的机遇。本文综述了系统生物学和代谢工程在乳酸菌生理功能的优化和调控中的具体应用。As cell factories, lactic acid bacteria are widely used in food, agriculture, medicine and other industries, and play a great role in industrial processes. However, lactic acid bacteria encounter various environmental stresses both in industrial processes and in the gastrointestinal tract, which impair their physiological functions and food manufacture efficiency. Recently, the development of metabolic engineering and system biology brings unprecedented opportunity for the physiological modification of lactic acid bacteria. In this review, we addresses the progress of lactic acid bacterium system biology, and based on this, the metabolic engineering strategies for manipulating and optimizing lactic acid bacteria physiological function were summarized.

关 键 词：乳酸菌 生理功能 代谢工程 系统生物学 

分 类 号：Q93[生物学—微生物学]