吸液缓溶性壬苯醇醚膜对皮肤黏膜刺激性和抑菌作用的研究  

The effects of imbibition-slow dissolving nonoxynol-9 membrane on skin/mucosal irritation and bacteriostasis

作　　者：李荣秀 李国正 赵凯军[2] 高羽 牛慧蒙 赵慧芬 

机构地区：[1]河北省计划生育科学技术研究院,石家庄050071 [2]河北省藁城市人民医院,藁城052160 [3]河北省承德市双滦区人民医院,承德067000

出　　处：《生殖医学杂志》2011年第6期511-514,共4页Journal of Reproductive Medicine

摘　　要：目的探讨吸液缓溶性壬苯醇醚膜对皮肤、黏膜的刺激性和抑菌作用。方法采用皮肤、阴道黏膜刺激试验方法和抑菌试验方法。结果吸液缓溶性壬苯醇醚膜对家兔皮肤刺激反应积分均值为0,按照刺激强度分级属无刺激性。阴道黏膜刺激试验,阳性对照组(壬苯醇醚膜)刺激指数为0.7,实验组(吸液缓溶性壬苯醇醚膜)刺激指数为0.3。吸液缓溶性壬苯醇醚膜作用10 min对金黄色葡萄球菌有抑制作用;作用5 min对大肠杆菌和白色念珠菌均有较强抑菌作用。壬苯醇醚膜对大肠杆菌和金黄色葡萄球菌抑菌作用较弱,对白色念珠菌无抑菌作用。膜基质片无抑菌作用。结论吸液缓溶性壬苯醇醚膜对皮肤无刺激性,阴道黏膜的刺激指数比壬苯醇醚膜明显降低,对细菌和真菌均具有明显的抑菌作用。Objective： To investigate the effects of imbibition-slow dissolving nonoxynol-9 （NP-9） membrane on skin/mucosa irritation and bacteriostasis. Methods： In vivo rabbit skin/vaginal irritation test and in vitro bacteriostasis test were employed, with imbibition-slow dissolving NP-9 membran as test material, NP-9 membrane as positive control, and imbibition-slow dissolving membran without NP-9 as negative control. Results. The average skin irritation index by imbibition-slow dissolving NP-9 membrane was 0. The average irritation index of vaginal mucosal irritation test was 0. 7 by NP-9 membrane, and 0. 3 by imbibition-slow dissolving NP-9 membrane. In contact with imbibition-slow dissolving NP-9 membrane for 10 minutes, the bacteriostasis of staphylococcus aureus was observed. Five minutes of contact with the imbibition-slow dissolving NP-9 membrane resulted in a strong bacteriostasis of colibacillus and candidaalbicans. The NP-9 membrane had a weak bacteriostatic effect on colibacillus and staphylococcus aureus, but no bacteriostatic effect on candidaalbicans. The membrane matrix （without NP-9） had no antimicrobial effect. Conclusions. The imbibition-slow dissolving NP-9 membranes had no irritant effect on skin and its vaginal mucosal irritation was waker than that of NP-9 membrane. It had an obviously inhibitory effect on bacteria and fungi.

关 键 词：吸液缓溶 壬苯醇醚-9(NP-9) 皮肤黏膜刺激 抑菌 

分 类 号：R[医药卫生]