G蛋白β3亚单位基因多态性与抗精神病药源性肥胖的相关性  

Association study between G-protein β3 subunit gene polymorphism and antipsychotic agent-induced obesity

作　　者：张文跃[1] 祁小飞[2] 杨忠[3] 王梅芬[1] 顾凤华[1] 宣春明 韩晓东[1] 

机构地区：[1]江苏省太仓市第三人民医院精神科,太仓215400 [2]苏州大学附属第一医院江苏省血液研究所 [3]江苏省常熟市第三人民医院精神科

出　　处：《中华行为医学与脑科学杂志》2011年第12期1101-1103,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：苏州市科技计划（社会发展）项目（SZD0971）;太仓市科技发展计划（社会发展）项目（TS0906）;太仓市卫生人才计划培养项目

摘　　要：目的探讨G蛋白β3亚单位（GNB3）基因C825T多态性与抗精神病药源性肥胖的关系。方法收集126例长期应用抗精神病药的精神分裂症患者，按体重指数（BMI）分成肥胖组（62例）和非肥胖组（64例）；采用聚合酶链式反应（PCR）和DNA测序技术测定GNB3基因C825T多态性；常规检测空腹血糖（FBG）、餐后2h血糖（2hPBG）、血脂、血尿酸（UA）水平。结果（1）肥胖组与非肥胖组均发现GNB3基因C825T多态性，并符合Hardy．Weinberg平衡率；（2）肥胖组基因型频率（CC17．75％，CT58．06％，TF24．19％）与非肥胖组（CC18．75％，CT62．50％，1Tr18．75％）比较差异无统计学意义（χ2=0．59，P〉0．05），肥胖组等位基因频率（C46．77％，T53．23％）与非肥胖组（C50％，T50％）比较差异也无统计学意义（χ2=0．26，P〉0．05）；（3）不同基因型之间BMI、FBG、2hPBG、血脂、uA水平差异无统计学意义（均P〉0．05），携T等位基因（CT型＋1Tr型）与非携T等位基因者（CC型）之间BMI、FBG、2hPBC、血脂、UA水平差异也无统计学意义（均P〉0．05）。结论GNB3基因C825T多态f生可能不是抗精神病药源}生肥胖的基因危险因素。Objective To explore the relationship between G-protein β3 subunit （GNB3） gene C825T polymorphism and antipsyehotic agent-induced obesity. Methods 126 schizophrenic inpatients with long-term antipsychotics treatment were collected. According to body mass index （BMI） , patients were divided into obesity group （ n = 62） and non-obesity group（ n = 64）. The GNB3 gene C825T polymorphism was detected by polytnerase chain reaction and DNA sequencing technique. Levels of fasting blood glucose,2-hour postprandial blood glucose, blood lipids and blood uric acid of all patients were routinely measured. Results （1）The GNB3 gene C825T poly- morphism were found in obesity group and non-obesity group respectively, and the distribution of genotypes in two groups were both consistent with Hardy-Weinberg equilibrium. （2）There was no significant difference in genotype frequencies between obesity group （ CC 17.75% ,CT 58.06% ,TT 24.19% ） and non-obesity group（ CC 18.75% , CT 62.50%,TT 18.75% ）（χ2 = 0.59, P 〉 0.05 ）. There was also no significant difference in allele frequencies between obesity group （ C 46.77%, T 53.23 % ） and non-obesity group （ C 50%, T 50% ） （ χ2 = 0.26, P 〉 0.05 ）. （3）No significant differences were observed in BMI, fasting blood glucose,2-hour postprandial blood glucose, blood lipids and blood uric acid among different genotype groups （all P 〉 0.05 ）. Also no significant differences were observed in BMI, fasting blood glucose,2-hour postprandial blood glucose, blood lipids and blood uric acid between T- allele carrier （ TT and CT genotypes） and T-allele non-carrier （ CC genotype） （ all P 〉 0.05 ）. Conclusion The GNB3 gene C825T polymorphism may not be a genetic risk factor for antipsyehotic agent-induced obesity.

关 键 词：G蛋白Β3亚单位 遗传学 多态性 抗精神病药 肥胖 

分 类 号：R749.3[医药卫生—神经病学与精神病学]