运动训练对大鼠冠状动脉TGFβ和TNFα表达的影响  

Effects of Exercises Training Intensity on Expression of TGFβ and TNFα in the Rats Coronary

作　　者：吴晓杰[1] 董听[1] 汪晓瑞[1] 田振军[1] 

机构地区：[1]陕西师范大学体育学院,西安710062

出　　处：《体育科技》2011年第4期61-64,共4页Sport Science and Technology

摘　　要：目的:探讨不同强度训练对大鼠冠状动脉TGFβ和TNFα表达的影响。方法:采用跑台训练方式建立大鼠有氧运动和疲劳运动模型,运用免疫组织化学SABC法研究不同运动强度对大鼠冠状动脉TGFβ和TNFα表达的影响。结果:有氧运动组与对照组比较,冠状动脉TGFβ的MOD值虽有降低但并不显著,TNFα的MOD值明显降低(P<0.05),疲劳运动组与对照组和有氧运动组比较,冠状动脉TGFβ和TNFα表达有显著性差异(P<0.05)。结论:有氧训练可使TGFβ和TNFα适度表达,疲劳训练会导致大鼠冠状动脉TGFβ和TNFα过量表达。因此认为运动训练与TGFβ和TNFα表达变化关系密切。Objective： To discuss the effect of different exercise intensity on expression of TGFβ and TNFα in the rat coronary. Method Use treadmill exercise to establish the models of aerobic exercised dandy fatigue exercise rats. We utilize immunohistochemistry of SABC to measure different exercise intensity to rat coronary TGFβ and TNFα expression. Result： Comparing between aerobic training group and control group, the MOD of TGFβ in coronary expression decreased but has no difference in three groups. The MOD of TNFα expression was significant. The fatigue group coronary TGFβ and TNFα expression compare with the control group and aerobic group were significant. Conclusion： Expression change of rats coronary TGFβ and TNFα was caused by exercise training also had a closed relation with the exercise intensity. Moderate expression of coronary TGFβ and TNFα could be caused by aerobic exercise, and the fatigue training could cause the rats coronary TGFβ and TNFα excessive expression. Therefore we believed that the exercise training causes the TGFβ and TNFα expression change.

关 键 词：运动训练 冠状动脉 大鼠 TGFΒ TNFΑ 免疫组织化学 

分 类 号：R87[医药卫生—运动医学]