2024年11月22日,上海交通大学基础医学院王琼研究团队等在Nature Communications上发表了题为“A stepwise mode of TGFβ-SMAD signaling and DNA methylation regulates naïve-to-primed pluripotency and differentiation”的研究成...
supported by the Basic Research Support Program for Outstanding Young Teachers of Heilongjiang Province(No.YQJH2023038);the National Natural Science foundation of China(Nos.82170431,82070312,82373868,82330011,and U21A20339);the Scientific Research Project of Provincial Scientific Research Institute of Heilongjiang Province(No.CZKYF2022-1-B007).
Endothelial-mesenchymal transition(EndMT)disrupts vascular endothelial integrity and induces atherosclerosis.Active integrinβ1 plays a pivotal role in promoting EndMT by facilitating TGFβ/Smad signaling in endotheli...
National Natural Science Foundation of China(31925013,U20A20393,32200575,W2411011 and 32460164);National Key R&D Program of China(2021YFA1101000).
Human stem cells are undifferentiated cells with the capacity for self-renewal and differentiation into distinct cell lineages,playing important role in the development and maintenance of diverse tissues and organs.Th...
supports from all parties during the Covid-19 pandemic;supported by(1)the National Key R&D Program of China(Project No.2019YFA0111900 to YJ),which is financed by the Ministry of Science and Technology of the People’s Republic of China(MOST,China);supported by a grant from the NSFC/RGC Joint Research Scheme sponsored by the Research Grants Council of the Hong Kong Special Administrative Region,China and the National Natural Science Foundation of China(Project No.N_CUHK483/22 to YJ);the Center for Neuromusculoskeletal Restorative Medicine[CNRM at InnoHK,to YJ,HC,PY]by Innovation and Technology Commission(ITC)of Hong Kong SAR,China;the Natural Science Foundation of China(Project No 82302728 to XZ);The Chinese University of Hong Kong.
Osteoarthritis(OA)is a major clinical challenge,and effective disease-modifying drugs for OA are still lacking due to the complicated pathology and scattered treatment targets.Effective early treatments are urgently n...