TGFβfamily signaling in human stem cell self‑renewal and differentiation  

作　　者：Sijia Liu Jiang Ren Yanmei Hu Fangfang Zhou Long Zhang 

机构地区：[1]International Biomed‑X Research Center,Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province,Second Affiliated Hospital of Zhejiang University School of Medicine,Zhejiang University,Hangzhou,China [2]The First Affiliated Hospital,MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors,Institute of Biomedical Innovation,School of Basic Medical Sciences,Jiangxi Medical College,Nanchang University,Nanchang,China [3]Department of Endocrinology and Metabolism,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China [4]The First Affiliated Hospital,the Institutes of Biology and Medical Sciences,Suzhou Medical College,Soochow University,Suzhou,China [5]MOE Key Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network,Life Sciences Institute,Zhejiang University,Hangzhou 310058,China

出　　处：《Cell Regeneration》2024年第1期62-82,共21页细胞再生(英文)

基　　金：National Natural Science Foundation of China(31925013,U20A20393,32200575,W2411011 and 32460164);National Key R&D Program of China(2021YFA1101000).

摘　　要：Human stem cells are undifferentiated cells with the capacity for self-renewal and differentiation into distinct cell lineages,playing important role in the development and maintenance of diverse tissues and organs.The microenvi-ronment of stem cell provides crucial factors and components that exert significant influence over the determination of cell fate.Among these factors,cytokines from the transforming growth factorβ(TGFβ)superfamily,including TGFβ,bone morphogenic protein(BMP),Activin and Nodal,have been identified as important regulators governing stem cell maintenance and differentiation.In this review,we present a comprehensive overview of the pivotal roles played by TGFβsuperfamily signaling in governing human embryonic stem cells,somatic stem cells,induced pluripotent stem cells,and cancer stem cells.Furthermore,we summarize the latest research and advancements of TGFβfam-ily in various cancer stem cells and stem cell-based therapy,discussing their potential clinical applications in cancer therapy and regeneration medicine.

关 键 词：TGFΒ BMP ESC IPSC Cancer stem cell 

分 类 号：R73[医药卫生—肿瘤]