青年短暂性脑缺血发作患者危险因素及预后随访研究  

Risk Factors and Prognosis in Youth Transient Ischemic Attack

作　　者：骆迪[1] 毕齐[1] 

机构地区：[1]首都医科大学附属北京安贞医院神经内科,北京100050

出　　处：《中国卒中杂志》2012年第1期17-22,共6页Chinese Journal of Stroke

摘　　要：目的对我院年龄在18～45岁青年短暂性脑缺血发作(transient ischemic attack,TIA)患者进行TIA危险因素及预后研究,指导临床治疗。方法回顾性的分析青年组(n=22)和中年及以上组(n=44)患者的临床资料,对两组患者的既往病史、TIA后7天内血管危险事件、脑血管病危险因素及相关检查指标进行比较。结果青年组的吸烟史高于中年及以上组(P<0.01);糖尿病史低于中年及以上组(P<0.01);体重、胆固醇、低密度脂蛋白胆固醇(low-density lipopr0tein cholesterol,LDL-c)高于中年及以上组(P值分别为0.03,0.022,0.04);高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-c)、空腹血糖、血浆纤维蛋白原低于中年及以上组(P值分别为0.014,0.009,0.048);两组TIA后7天内动脉硬化性血栓(angiosclerosis thrombus,AT)事件及缺血性卒中事件的发生率在中年及以上组(45岁以上)人群中有增高趋势,但差异无统计学意义。结论推测青年TIA的主要危险因素包括体重、胆固醇、LDL-c及吸烟史;相对于青年TIA惠者,糖尿病史和纤维蛋白原过高可能对45岁以上TIA患者产生更大的影响。Objective Researching in youth transient ischemic attack（TIA）（18-45 years old） in our hospital, to analyze its risk factors and prognosis, in order to guide clinical treatment. Methods To analyze the clinical data of the patients retrospectively, The patients were divided into young group（n=22）, middle-aged and above group（n=44）, to compare their previous history, TIA vascular risk events within the 7 d, cerebrovascular disease risk factors and related inspection indicators between the two groups. Results Smoking history in young group is longer than in middle-aged and above group（P〈0.01）; Diabetes history in young group is shorter than in middle-aged and above group（P〈0.01）; weight, cholesterol（P=0.022）, low density lipoprotein cholesterol（P=0.04） level are higher than in middleaged and above group（P=0.03, 0.022, 0.44 respectively）; High-density lipoprotein cholesterol, fasting blood glucose, plasma fibrinogen level in young group are lower than in middle-aged and above group（P=0.014, 0.009, 0.048 respectively）; TIA vascular risk events within the 7 d have no statistical difference; but the incidence is much higher in middle-aged and above group（over 45 years）. Conclusions We speculate that major risk factors in youth TIA include weight, cholesterol, low density lipoprotein cholesterol and smoking history. Diabetes history and higher fibrinogen may have more impact on TIA patients over 45 years, comparing with young group.

关 键 词：脑缺血发作 短暂性 病史记录 危险因素 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]