表皮生长因子受体与肺脏发育的关系  

Relationship of epidermal growth factor receptor in lung development

作　　者：李海静[1,2] 刘岩[2] 郝海生[2] 杜卫华[2] 赵学明[2] 王栋[2] 秦彤[2] 马友记[1] 朱化彬[2] 

机构地区：[1]甘肃农业大学动物科学技术学院,兰州730070 [2]中国农业科学院北京畜牧兽医研究所,北京100193

出　　处：《遗传》2012年第1期27-32,共6页Hereditas（Beijing)

基　　金：转基因重大专项(编号:2009ZX08011-031B和2009ZX08010-015B);基本科研业务费(编号:2011cj-11)资助

摘　　要：表皮生长因子受体(Epidermal growth factor receptor,EGFR)是一种跨膜蛋白受体,是ErbB家族成员之一,具有酪氨酸激酶活性。EGFR与相应的配体结合引起EGFR形成同源或异源二聚体启动胞内信号转导,激活下游多种信号转导途径,产生生物学效应,RAS/RAF/MEK/ERK通路与细胞增殖、分化和凋亡有关;PI3K/PDK1/AKT通路与细胞的迁移和粘附有关。EGFR能促进肺泡II型上皮细胞的成熟和肺表面活性物质的合成、分泌。EGFR对哺乳动物肺脏的作用呈现时空效应及剂量依赖效应,EGFR的下调表达则会引起肺脏发育不成熟;而EGFR过度表达促进肺肿瘤细胞的增殖、侵袭和转移。文章综述了EGFR及其调节信号通路的研究进展,以及EGFR与动物肺脏发育不成熟和肺癌之间的关系。The epidermal growth factor receptor （EGFR）, a transmembrane protein receptor, is a member of ErbB fam- ily with signal-transducing tyrosine kinase activity. After combined with the ligand, EGFR homologous or heterologous dimers are formed to induce intracellular signal transduction, activate downstream signal transduction pathways, and then produce a series of biological effects. RAF/MEK/RAS/ERK pathway is relevant to cell proliferation, differentiation and apoptosis; while PDK1/AKT/PI3K pathway is involved in cell migration and adhesion. EGFR can promote the maturity of pulmonary type II epithelial cells and the synthesis and secretion of pulmonary surfactant. EGFR shows the effect on mammal lungs in a time-space and dose-dependent manner. The down-regulated expression of it will lead to immature lung development, while the over-expression can promote the cell proliferation, invasion and metastasis of the lung cancer cells. This paper reviewed advances in the study for EGFR and its signal pathway, as well as the relationship among EGFR, atelectasis and lung cancer.

关 键 词：EGFR 肺泡Ⅱ型上皮细胞 肺脏表面活性物质 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]