阿德福韦酯联合香菇多糖治疗慢性乙型肝炎疗效观察  

Effect Analysis of Adefovir and Lentinan on Chronic Hepatitis B Patients

作　　者：陈玉琴[1] 吴群[1] 张义翠[1] 刘小兵[1] 

机构地区：[1]四川省科学城医院传染科,四川省绵阳市621900

出　　处：《医学理论与实践》2012年第4期383-384,共2页The Journal of Medical Theory and Practice

摘　　要：目的:观察阿德福韦酯联合香菇多糖治疗慢性乙型病毒性肝炎的临床疗效。方法:将68例慢性乙型病毒性肝炎患者随机分为对照组和治疗组各34例,对照组给予阿德福韦酯10mg/次,1次/d;治疗组在对照组的基础上加用香菇多糖15mg/次,2次/d,两组疗程均为12个月。结果:治疗组肝功能复常率、HBeAg阴转率、HBeAg/抗HBe转换率和HBV-DNA阴转率均比对照组高,经比较差异有统计学意义(P<0.05)。结论:阿德福韦酯联合香菇多糖治疗慢性乙肝的疗效明显优于单用阿德福韦酯。Objective：To analyze the effect of adefovir and lentinan on chronic hepatitis B patients.Methods：68 cases with chronic hepatitis B,were randomly divided into control group（34 cases）and treatment group（34 cases）,the control group was given adefovir,10mg/time,1 time/d,while treatment group received adefovir and lentinan,the lentinan 15mg/time,2 times/d.The all patients received treatment for 12 months.Results：Patients＇normalization,negative conversion rate of HbeAg,HBeAg/anti-HBeAg seroconversion rate,and negative conversion rate of HBV-DNA in the treatment group were higher than in the control group（P0.05）.Conclusion：Adefovir and lentinan have a good efficacy than adefovir only on chronic hepatitis B patients.

关 键 词：阿德福韦酯 香菇多糖 慢性肝炎 乙肝病毒 治疗效果 

分 类 号：R575.1[医药卫生—消化系统]