内蒙古产白刺、小果白刺和霸王α-葡萄糖苷酶抑制活性  

α-Glucosidase Inhibitory Activitives of S.xanthoxylon Bunge,N.tangutorum Bobr and N.sibirica Pall,grown in Neimenggu from Zygophyllaceae

作　　者：常星[1,2] 康文艺[2] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193 [2]河南大学中药研究所,开封475004

出　　处：《天然产物研究与开发》2012年第2期216-218,238,共4页Natural Product Research and Development

基　　金：河南省教育厅基础研究计划(2008A360002);河南省教育厅青年骨干教师资助计划(教高2008-755)

摘　　要：首次利用体外α-葡萄糖苷酶抑制模型对内蒙古产3种蒺藜科植物的9个提取物进行活性评价,并与阳性对照Acarbose比较,发现3种植物均有抑制α-葡萄糖苷酶活性。其中白刺石油醚提取物对α-葡萄糖苷酶的抑制活性(IC50=81.80 mg/L)最高,其余依次为小果白刺乙酸乙酯提取物(IC50=610.29 mg/L),霸王石油醚(IC50=627.22 mg/L)和乙酸乙酯提取物(IC50=838.40 mg/L),它们的抑制活性远大于阳性对照Acarbose(IC50=1103.01 mg/L)。结果发现,不同植物不同溶剂提取物的α-葡萄糖苷酶抑制活性不同。同一植物不同溶剂提取物相比较,甲醇提取物的α-葡萄糖苷酶抑制活性不及乙酸乙酯和石油醚提取物。The α-glucosidase inhibitory activities of nine extracts from three species of Zygophyllaceae in Neimenggu were evaluated in vitro by 96-microplate-based method for the first time.All these three species showed α-glucosidase inhibitory activities compared with the positive control ＂acarbose＂.Among these nine extracts,petroleum ether extract of Nitraria tangutorum Bobr.had the highest inhibitory activity（IC50=81.80 mg/L）,followed by the ethyl acetate extract of N.sibirica Pall（IC50=610.29 mg/L）,the petroleum ether extract（IC50 =627.22 mg/L） and ethyl acetate extract（IC50=838.40 mg/L） of Sarcozygium xanthoxylon Bunge,all of which are much higher than that of acarbose（IC50=1103.01 mg/mL）.Different extracts of different plants showed different inhibitory activies,while the inhibitory activity of different extracts from the same plant varied a lot.The methanolic extract had lower inhibitory activity than that of ethyl acetate extract and petroleum ether extract.

关 键 词：蒺藜科 霸王 白刺 小果白刺 Α-葡萄糖苷酶 抑制活性 

分 类 号：Q946.81[生物学—植物学] R285[医药卫生—中药学]