2-O-(庚氧基-2-羟丙基)-β-环糊精的制备及其包埋性能  

Synthesis of 2-(heptyloxy-2-hydroxypropyl)-β-cyclodextrin and Its Embedding Properties

作　　者：郭艳玲[1] 王宝琦[2] 崔昭山[2] 姜川[2] 

机构地区：[1]天津科技大学理学院,天津300457 [2]天津科技大学材料科学与化学工程学院,天津300457

出　　处：《天津科技大学学报》2012年第1期27-30,共4页Journal of Tianjin University of Science & Technology

基　　金：天津市生物医学材料重点实验室开放课题基金资助项目(2011-1116-1)

摘　　要：为了改善β–环糊精的包埋效果和保护能力,以正庚基缩水甘油醚和β–环糊精为原料,在1.5%的氢氧化钠碱性介质中反应,合成单取代烷基缩水甘油醚β–环糊精,并用FTIR、1H NMR、TGA进行了结构表征.分别用β–环糊精和2–O–(庚氧基–2–羟丙基)–β–环糊精对辣椒红色素进行包埋,结果表明:2–O–(庚氧基–2–羟丙基)–β–环糊精的包埋率比β–环糊精的多1倍,保护能力也得到有效提高.For improving the embedding effect and protection ability of β-cyclodextrin, 2-（heptyloxy-2-hydroxypropyl）-β-cyclodextrin was synthesized in a 1.5% of sodium hydroxide solution using heptyl glycidyl ether and β-cyclodextrin as raw materials. The product＇s structures were proved by the FTIR, 1H NMR and TGA. The paprika oleoresin was embedded with β-cyclodextrin and substituted β-cyclodextrin, and the embedding ratio and stability of the two complexes were contrasted. The results show that the embedding ratio offl-cyclodextrin derivate is two times as many as β-cyclodextrin and its protection ability has also been improved effectively.

关 键 词：缩水甘油醚 β–环糊精衍生物 辣椒红色素 包埋率 

分 类 号：O621[理学—有机化学]