New Understandings on Folliculogenesis/Oogenesis Regulation in Mouse as Revealed by Conditional Knockout  

作　　者：Meng-Wen Hu Zhen-Bo Wang Heide Schatten Qing-Yuan Sun 

机构地区：[1]a State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [2]Graduate School of Chinese Academy of Sciences,Beijing 100101,China [3]Department of Veterinary Pathobiology,University of Missouri,Columbia,MO 65211,USA

出　　处：《Journal of Genetics and Genomics》2012年第2期61-68,共8页遗传学报（英文版）

基　　金：supported by the National Basic Research Program of China(Nos.2011CB944501 and 2012CB944404);the National Natural Science Foundation of China(No. 30930065)

摘　　要：In comparison to conventional knockout technology and in vitro research methods, conditional gene knockout has remarkable advantages. In the past decade, especially during the past five years, conditional knockout approaches have been used to study the regulation of folliculogenesis, follicle growth, oocyte maturation and other major reproductive events. In this review, we summarize the recent findings about folliculogenesis/oogenesis regulation, including the functions of four signaling cascades or glycoprotein domains that have been extensively studied by conditional gene deletion. Several other still fragmented areas of related work are introduced which are awaiting clarification. We have also discussed the future potential of this technology in clarifying gene functions in reproductive biology.In comparison to conventional knockout technology and in vitro research methods, conditional gene knockout has remarkable advantages. In the past decade, especially during the past five years, conditional knockout approaches have been used to study the regulation of folliculogenesis, follicle growth, oocyte maturation and other major reproductive events. In this review, we summarize the recent findings about folliculogenesis/oogenesis regulation, including the functions of four signaling cascades or glycoprotein domains that have been extensively studied by conditional gene deletion. Several other still fragmented areas of related work are introduced which are awaiting clarification. We have also discussed the future potential of this technology in clarifying gene functions in reproductive biology.

关 键 词：Conditional knockout FOLLICULOGENESIS OOGENESIS MOUSE 

分 类 号：Q959.4[生物学—动物学] S823.3[农业科学—畜牧学]