脑血管病患者血浆降钙素基因相关肽的测定及临床意义  

作　　者：孙琳[1] 李义召[2] 张东君[2] 刘爱芬[2] 刘言训[3] 刘建伟[2] 李明欣 迟兆富[2] 韩丹春[2] 

机构地区：[1]山东医科大学第二附属医院,250033 [2]山东医科大学第一附属医院 [3]山东医科大学公共卫生学院

出　　处：《山东医药》2000年第3期14-16,共3页Shandong Medical Journal

摘　　要：采用放免法测定了108例脑血管病(CVD)患者的血浆降钙素基因相关肽(CGRP)水平。结果62例脑梗塞(CI)患者(CI组)显著低于对照组,发病24小时内即显著降低,2～7天进一步降低;8～15天开始升高,15天后逐渐升至正常水平;46例脑出血(CH)患者(CH组)亦显著低于对照组,发病15天以内的变化规律同CI组;发病15天虽进一步升高,但仍低于正常水平。提示随病情加重,脑出血量或梗塞面积增加,血浆CGRP水平明显降低。认为CI、CH患者存在CGRP分泌异常,CGRP参与了CVD的病理生理过程;CGRP水平动态检测可作为估计病情严重程度、病灶大小及预后的重要指标,调整CGRP的分泌将有助于改善CVD患者的预后。The levels of calcitonin gene related peptide of plasma of 108 patients with cerebrovascular disease were measured by radioimmunoassay The results showed that the level of plasma calcitonin gene related peptide in cerebral infarction group(62 cases)cut down more than that in control group The plasma calcitonin gene related peptide strated to decrease significantly in cerebral infarction group during the first day It decreased further on 1 to 3day and 4 to 7day,It started to increase from the eighth day,it was normal level after 15 day The level of plasma calcitonin gene related peptide in cerebral hemorrhage cut down more than that in control group The regular changs of plasma calcitonin gene related peptide in group of cerebral hemorrhage(46 cases)was as same as during day 15 It started to increase from day 15,but it was also lower than that in control group The results also showed that there was a significant correlation between the levels of plasma calcitonin gene related peptide and the patient's condition and the size of focus of infection of cerebral infarction,cerebral hemorrhage This suggests calcitonin gene related peptide play a major role in pathophysiological and pathogenetic mechanisms of cerebral infarction and cerebral hemorrhage

关 键 词：脑血管病 CVD CGRP 

分 类 号：R743.02[医药卫生—神经病学与精神病学]