组织微阵列方法检测let-7b在乳腺癌组织中的表达  

Tissue microarray method to detect the expression of let-7b in breast cancer tissue and its significance

作　　者：马琳[1,2] 李贵柱[3] 孟刚[1] 

机构地区：[1]安徽医科大学病理学教研室,安徽合肥230032 [2]蚌埠医学院病理生理学教研室,安徽蚌埠233030 [3]安徽省合肥市第二人民医院病理科,230011

出　　处：《蚌埠医学院学报》2012年第2期148-150,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨let-7b在乳腺癌组织中的表达。方法:建立组织微阵列,应用原位分子杂交检测80例人乳腺癌组织和22例乳腺良性病变组织中let-7b的表达。结果:乳腺癌组织中let-7b阳性率为35.0%,低于乳腺良性病变组织中的59.1%(P<0.05)。结论:let-7b低表达可以促进乳腺癌的发生、发展。Objective：To investigate the expression of let-7b in breast cancer. Methods：Using tissue microarray platform and applying in situ molecular hybridization technique for detecting the expression of let-Tb in 80 cases of human breast cancer, 22 cases of benign breast disease. Results：The positive rates of let-7b was 35.0% in the breast cancer, it. was lower than 59.1% in the benign breast disease（P 〈0.05 ）. Condusions： Down-regulation of let-Tb expression might play a role in the pathogenesis and progression of breast

关 键 词：乳腺肿瘤 let-7b MIRNA 

分 类 号：R730.7[医药卫生—肿瘤]