高脂饮食与阿尔采末病之间关系的研究进展  

Research progress on the relationship betweenhigh-fat diet and Alzheimer's disease

作　　者：何鑫[1,2] 胡金凤 苑玉和 楚世峰 韩宁 陈乃宏 

机构地区：[1]天然药物活性物质与功能国家重点实验室,中国医学科学院药物研究所,北京100050 [2]天津中医药大学研究生院,天津300193

出　　处：《中国药理学通报》2012年第3期297-300,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 30801527,30973887,U832008,90713045)

摘　　要：近年来研究发现,高脂饮食(高胆固醇)是阿尔采末病(AD)发病的危险因素之一,高脂饮食能够增加AD的发病率,但胆固醇不能透过血脑屏障进入脑内,所以高脂饮食不能直接导致AD的发生,它是通过何种途径引发AD是许多研究者关注的热点。该文主要围绕高脂饮食引发AD发病的可能机制的研究进展进行了阐述。In recent years,it has been found that high fat-diet（high-cholesterol diet） is one of the risky factors for developing Alzheimer＇s disease（AD）,and it can increase the morbidity rate of AD.It is well known that cholesterol can not cross the blood-brain barrier and enter the brain from the blood,which implies that high-fat diet can not directly induce the occurrence of AD.Now,many researchers focus on studying the reasons of AD occurrence induced by high-fat diet.This review reports the current research progress on the possible mechanisms of how the high-fat diet causes AD.

关 键 词：高脂饮食 AD AΒ 神经炎症 突触可塑性 学习记忆 

分 类 号：R-05[医药卫生] R344.81