浙江省台州市椒江区人群碘营养状况研究  

A Survey on Iodine Nutrition Condition of Residents in Jiaojiang District,Taizhou City,Zhejiang Province

作　　者：杨年忠[1] 陈莹[2] 杨文渊[3] 包先金 郝伟[4] 周金水[5] 

机构地区：[1]台州市椒江区疾病预防控制中心慢性病防治科,浙江台州318000 [2]浙江省台州医院内科,浙江临海317000 [3]广西医科大学,广西南宁530021 [4]台州市疾病预防控制中心检验检测中心,浙江台州318000 [5]浙江省疾病预防控制中心环境与健康监测所,浙江杭州310051

出　　处：《环境与职业医学》2012年第3期148-153,共6页Journal of Environmental and Occupational Medicine

摘　　要：[目的]了解浙江省台州市椒江区居民碘营养和甲状腺疾病状况。[方法]2010年4—6月,采用横断面调查研究,分层整群抽样法,调查3个村311户居民,尿碘检查944人,甲状腺检查793人。B超法检查甲状腺,砷铈催化分光光度法测定尿碘浓度,化学发光免疫测定法检测甲状腺激素,直接滴定法检测盐碘含量。[结果]检查793人,查出甲状腺结节182例,患病率为22.95%,甲状腺结节患病率随年龄增大而上升（χ2=72.12,P=0.001）;其中6~14岁组患病率为0.00%,≥15岁组患病率为25.60%,两组差异有统计学意义（χ2=27.24,P=0.001）;女性患病率（26.97%）明显大于男性（17.82%）（χ2=9.25,P=0.002）。调查8~10岁儿童31人,甲状腺肿大率为0.00%。尿碘〈100μg/L组甲状腺结节患病率大于≥100μg/L组（χ2=12.50,P=0.007）。标化患病率百果村为19.44%、高张村为26.43%、华景村为19.42%。944人尿碘中位数（median urinary iodine,MUI）为178.25μg/L,其中儿童185.85μg/L、孕妇138.50μg/L、哺乳妇女181.40μg/L、普通人群176.00μg/L,百果村184.40μg/L、高张村152.00μg/L、华景村192.00μg/L。孕妇33人中,甲状腺球蛋白抗体（thyroglobulinantibody,TgAb）和甲状腺过氧化物酶抗体（thyroid peroxidase antibody,TPOAb）阳性者2例,阳性率6.06%。在B超检查异常的178人中,游离三碘甲腺原氨酸（free triiodothyronine,FT3）升高者171例,占96.07%;游离甲状腺素（free thyroxine,FT4）和总甲状腺素（total thyroxine,TT4）均升高者178例,占100.00%;总三碘甲腺原氨酸（total triiodothyronine,TT3）升高者159例,占89.33%;促甲状腺素（thyrotropin,TSH）异常者11例（减低3例,升高8例）,异常率6.18%;TgAb和TPOAb阳性者27例,阳性率15.17%。调查311户中,碘盐覆盖率77.50%,碘盐合格率90.30%,合格碘盐食用率74.34%,盐碘均值28.74mg/kg。检测自来水9份,水碘中位数2.2μg/L。[结论]椒江区人群碘营养处于适宜状态,孕妇碘营养不足,碘盐作为甲�[ Objective ] To understand the prevalence of thyropathy among the residents of Jiaojiang District and relatediodine nutrition condition. [ Methods ] A cross-sectional design survey was conducted among residents of 311 households in 3 villages by stratified cluster sampling from April through June. A t.otal of 944 subjects were registered to urinary iodine test （arsenic-cerium catalyzed spectrophotometry） and 793 to type-B ultrasound thyroid examination. Other tests included chemiluminesent immunoassay for thyroid hormone and direct titration for iodine in table salt. [ Results I The thyroid nodule rate was 22.95% （182/793） and increased with age （x^2=72.12, P=0.001）. The difference of thyroid nodule rate between the 6-14 years group （0.00%） and the≥ 15 years group （25.60%） was statistically significant （x^2=27.24, P=0.001）, and that between female （26.79%） and male （17.82%） was also found statistically significant （x^2=9.25, P=0.002）. No enlarged thyroid was found in the 31 children （8-10-year-old）. The prevalence rate of thyroid nodule in the group of urinary iodine 〈100 μg/L was higher than that in the group of urinary iodine I〉 100μg/L （x^2=12.50, P=0.007）. The standardized prevalence rates in Baiguo Village, Gaozhang Village and Huajing Village were 19.44%, 26.43% and 19.42% respectively. The median urinary iodine （MUI） of all944 residents was 178.25 μtg/L, with 185.85 μg/L for the children investigated, 138.50 μg/L for the pregnant females, 181.40 μg/L for the lactating females, 176.00 μg/L for the general population, 184.40μg/L for Baiguo Village, 152.00 μg/L for Gaozhang Village and 192.00μg/L for Huajing Village. Among the pregnant females examined, 6.06% （2/33） were found positive in both thyroglobulin antibody （TgAb） and thyroid peroxidase antibody （TPOAb）. Among the 178 participants with B-type ultrasonic abnormalities, an elevated free triiodothyronine （FT3） was found in 171 cases （96.07%）; elevated free thyroxine （

关 键 词：碘 甲状腺 尿碘 碘盐 人群 

分 类 号：R151.2[医药卫生—营养与食品卫生学]