益生菌以及益生元在肥胖及其代谢综合征中的潜在作用  

The potenial function of probiotics and prebiotics in obesity and associated metabolic disorders

作　　者：廖文艳[1] 苏米亚[1] 周杰[1] 沈玲[1] 徐致远[1] 王豪[1] 

机构地区：[1]光明乳业股份有限公司技术中心 乳业生物技术国家重点实验室,上海200436

出　　处：《中国微生态学杂志》2012年第3期286-288,F0003,共4页Chinese Journal of Microecology

基　　金：上海乳业生物工程技术研究中心(09DZ2251400);乳业生物技术国家重点实验室筹建(10dz2221100)

摘　　要：肥胖以及相关的代谢综合征已经成为全球性的公共健康问题。大量的研究表明,肥胖形成以及减肥过程均与肠道菌群密切相关且相互影响。肠道菌群以及弱炎症反应成为肥胖以及相关代谢综合征的两大重要影响因素。本文综述了近几年来,肠道菌群失调对宿主能量储存以及新陈代谢的影响,以及弱炎症反应对肥胖引起的代谢综合征的影响。大量的研究证明,益生元有助于益生菌的生长,而益生菌可以调节肠道菌群以及改善肠道内弱炎症反应,借助于益生菌以及益生元的方法也许能为由肠道菌群失调以及弱炎症反应引起的肥胖及其代谢综合征提供一种新的治疗方法。Obesity and the associated metabolic disorders have been the worldwide public healthy problems. The development of obesity and the process of losing weight are associated with the intestine microbiota. Recent literatures indicate that the intestinal microbiota dysbiosis and low grade inflammation have been the two main factors affecting the development of obestiy and the related metabolic disorder. This review focuses on recent sdudies on how intestinal microbiota affects host metabolism and energy storage. It also reviews the interaction between obesity, intestinal microbiota, and low grade inflammation. Considering the functions of the probiotics and prebiotics, probiotics and prebiotics approaches appear as a potential treatment to control the obesity linked to gut microbiota dysbiosis and the metabolic disorder related to obesity.

关 键 词：益生菌 益生元 肥胖 肠道菌群 弱炎症反应 

分 类 号：R378[医药卫生—病原生物学]