基于空间频率通道的弱视眼与正常眼对比敏感度的差异分析  

Variance analysis of contrast sensitivity for amblyopia and normal eye based on spatial frequency channels

作　　者：王丽萍[1] 张江瑾[2] 邱飞岳[3] 陈宏[3] 孙朝晖[4] 

机构地区：[1]浙江工业大学智能信息处理研究所,杭州310014 [2]浙江工业大学经贸管理学院,杭州310014 [3]浙江工业大学教育科学与技术学院杭州310014 [4]浙江大学医学院附属第二医院眼科中心,杭州310009

出　　处：《中华实验眼科杂志》2012年第4期349-352,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金资助项目（61070135）、浙江省自然科学基金资助项目（R2080100）、浙江省科技计划项目（2009C33133）

摘　　要：背景对比敏感度（cs）作为弱视诊疗手段之一在临床中已广泛应用，但其与空间频率通道之间的相互影响还有待研究。目的比较儿童弱视眼与正常眼的CS，通过空间频率通道探讨弱视眼cs缺损的原因。方法采用OPTEC6500型视功能测试仪对166眼正常眼和143眼弱视眼进行CS测量，通过主成分分析法和非正交旋转法推导空间频率通道的调谐曲线，由半高宽法计算通道带宽，比较通道数目和通道带宽，对弱视眼和正常眼的CS进行差异分析。空间频率通道的有效性采用43眼弱视眼cs数据进行交叉验证。结果在空间频率为1．5、3．0、6．0、12．0、18．0cpd时，弱视眼CS分别为：36．35±21．40、50．33±33．46、46．88±41．72、16．24±17．26、4．67±5．79；正常眼CS分另1为：49．49±24．69、87．23±40．87、93．18±51．99、36．63±24．72、15．70±13．87（H=27．83、66．61、68．34、78．23、89．88，P〈0．05）。弱视眼和正常眼的CS存在三个空间频率通道；在空间频率峰值为3．0、6．0、12．0cpd时，正常眼的通道带宽分别为1．03、1．02、0．99 octaves，弱视眼的通道带宽分别为1．04、1．01、0．73octaves。结论弱视眼cs的缺损可能由对应空间频率通道带宽的缩小引起。Background Contrast sensitivity （CS）of amblyopia has been extensively studied, but its relationship with spatial frequency channels needs further research. Objective The purpose of this study was to investigate the reasons of the CS deficits in amblyopia through comparing the differences in CS between amblyopic and normal eyes from the point of view of spatial frequency channels. Methods The CS values of 166 normal children eyes and 143 amblyopic children abnormal eyes were measured by adopting OPTEC 6500. Then, spatial frequency channels＇ tuning curves were derived via principal component analysis and non-orthogonal rotation. Also,numbers and bandwidths of channels were calculated using the method of full width at half maximum （ FWHM ）. All of these were used to analyze the variations of CS between amblyopia and normal eyes by comparing the numbers and the bandwidths of the channels. The reliability of spatial frequency channel was verified by a cross-validation study of 43 amblyopic children. Result At spatial frequency of 1.5,3.0,6.0,12.0,18.0 cpd, the mean of CS of amblyopia were 36.35±21.40,50.33 ± 33.46,46.88 ± 41.72,16.24 ± 17.26,4.67 ± 5.79, and the mean of CS of normal eyes were 49.49±24.69,87.23±40.87,93. 18±51.99,36.63±24.72,15.70± 13.87, with the rank-sum test results were H=27.83,66.61 , 68.34,78.23,89.88, P〈0. 05. There existed three spatial frequency channels in both amblyopia and normal eyes. At the peaks of 3.0,6.0 and 12.0 cpd, the bandwidths of normal eyes were 1.03,1.02 and 0.99 octaves,and the bandwidths of amblyopia were 1 bandwidths of the corresponding spatial frequency channels may cause the CS defieits in arnblyopia.

关 键 词：对比敏感度 空间频率通道 差异分析 弱视 

分 类 号：R777.44[医药卫生—眼科]