脂肪酶催化缩聚法合成可完全降解的聚羟基丙酸酯(英文)  

Synthesis of Polyhydroxyalkanoates by Polymerization of Methyl 3-Hydroxypropionate in the Catalysis of Lipase

作　　者：宋昊[1,2] 赵永杰[1] 张颖鑫[1,2] 孔维宝[1,2] 夏春谷[1] 

机构地区：[1]中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室,甘肃兰州730000 [2]中国科学院研究生院,北京100049

出　　处：《催化学报》2012年第3期432-438,共7页

基　　金：国家自然科学基金(21133011)~~

摘　　要：以3-羟基丙酸甲酯为聚合单体,建立了以固定化脂肪酶Novozym 435为催化剂的酶催化缩聚反应体系,合成可完全降解的高分子聚酯聚羟基丙酸酯,考察了反应条件和介质对反应性能的影响,结果表明,纯度大于95%的单体即可在温和条件下合成聚羟基羧酸酯;降低反应压力可有效提升产物产率和分子量.通过选择合适的有机溶剂介质和表面活性剂,可使产物分子量提升至13000(Mw)以上.脂肪酶催化剂重复利用能力优异,经6批次反应后,其相对活性保持在95%以上.The polymerization of methyl 3-hydroxypropionate as monomer catalyzed by lipase was selected as a model system in this study. The monomer with the purity around 95% could be polymerized to polyhydroxyalkanoates in the catalysis of Novozym 435. Decreasing the reaction pressure would result in the increase of product yield and high molecular weight. By choosing appropriate organic solvents, surfactants and reaction pressure, the molecular weight of polyhydroxy propionate polyester could be controlled from 1800 to 13000 （Mw value）. The reusing ability of enzymatic catalyst was comparatively good. The relative activity could be maintained above 95% after 6 repeated batches reaction.

关 键 词：聚羟基羧酸酯 聚合 酶催化 脂肪酶 3-羟基丙酸甲酯 

分 类 号：O631.5[理学—高分子化学]