天冬氨酸家族主要氨基酸高产菌株的选育策略  

Metabolic Engineering Strategies of Bacterial Strains for Overproduction of L-Threonine and L-Lysine

作　　者：吴瑶瑶[1] 裘娟萍[1] 

机构地区：[1]浙江工业大学生物与环境工程学院,浙江杭州310014

出　　处：《氨基酸和生物资源》2012年第1期35-41,共7页Amino Acids & Biotic Resources

摘　　要：L-苏氨酸与L-赖氨酸是L-天冬氨酸家族氨基酸(AFAAs)中的重要成员,近年来由于其在食品、化妆品、动物饲料添加剂等方面的广泛应用而备受关注,市场需求逐年上升。运用代谢工程手段构建高产菌,可有效地提高L-苏氨酸和L-赖氨酸的生产水平。本文详述了L-苏氨酸与L-赖氨酸的合成途径、调控机制以及两种氨基酸高产菌株的构建策略。L-Threonine and L-lysine,two of the L-aspartate family amino acids（AFAAs）,have attracted great attention because of their wide application in industries of food,animal feeding and cosmetics.Metabolic engineering of bacterial strains significantly improved the production of L-threonine and L-lysine.Here,biosynthetic pathways and regulations of L-threonine and L-lysine are summarized.The strategies of metabolic engineering for the development of L-threonine and L-lysine overproducers are also discussed.

关 键 词：L-苏氨酸 L-赖氨酸 代谢工程 

分 类 号：TQ922[轻工技术与工程—发酵工程]