电针治疗猕猴脑缺血及再灌后脑内氨基酸的变化  

The levels of amino acids after electro-acupuncture and ischemia in rhesus monkeys

作　　者：甘平[1,2,3] 李群[1] 高焕民[2] 郭景春[3] 程介士[3] 

机构地区：[1]昆明医学院,云南昆明650500 [2]青岛医学院第二附属医院,山东青岛266042 [3]复旦大学上海医学院,上海200032

出　　处：《中医临床研究》2012年第6期16-17,19,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:电针对脑缺血的保护作用,以往的实验数据均在大鼠身上获得,而大鼠的身体结构和经络与人体有着较大差异,为了进一步探索针刺治疗脑缺血的作用机制。方法:本实验以成年健康猕猴(雌雄各半)为实验对象,采用大脑中动脉阻塞再灌模型,猕猴在缺血2h,再灌9h后,在其督脉穴位:百会和人中进行电针治疗。用毛细管区带电泳检测猕猴脑匀浆组织中八种氨基酸的变化。结果:发现GABA,Tau,Gly,Gln和Asn的水平在缺血后级电针治疗后没有明显变化。而Glu和Asp在缺血后急速升高,经电针治疗后几乎下降到正常水平。结论:电针可有效降低因缺血再灌后造成的兴奋性氨基酸的异常升高。Objective：Electro-acupuncture had neuro-protection from ischemia,the experimental data obtained in rats,the rat＇s body structure and meridians were quite different from the Mankind＇s,To further investigate the mechanism of electro-acupuncture（EA） following ischemia.Methods：Adult health rhesus monkeys（male and female） were used in the study.Eight amino acids were detected by capillary-zone electrophoreses after monkey following ischemia and EA treatment on Dumai acupoint：Ren Zhong and Bai Hui.Results： there were not obvious changes in these amino acids：GABA,Tau,Gly,Gln and Asn.While Glu and Asp were increased after ischemia and decreased after EA treatment.Conclusion：EA played a role on decreasing the abnormal increased excitatory amino acids levels.

关 键 词：脑缺血 电针 猕猴 督脉穴位 氨基酸 

分 类 号：R743.31[医药卫生—神经病学与精神病学]